{"id":"W2767038995","doi":"10.1038/ng.3977","title":"Exome-wide association study of plasma lipids in >300,000 individuals","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":595,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"FP7 Ideas: European Research Council; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Medical Research Council; Directorate for Biological Sciences; Novo Nordisk Fonden; Faculty of Health and Medical Sciences, University of Western Australia; Rigshospitalet; British Heart Foundation; NIHR Exeter Clinical Research Facility; European Hematology Association; Sarnoff Cardiovascular Research Foundation; Perelman School of Medicine, University of Pennsylvania; Vanderbilt University Medical Center; Steno Diabetes Center Copenhagen; Wellcome Trust; National Institutes of Health; Regeneron Pharmaceuticals; Lundbeckfonden; Eli Lilly and Company; AstraZeneca; National Institute for Health and Care Research; Quest Diagnostics; Gentofte Hospital; Bayer HealthCare; Donovan Family Foundation; National Institute on Drug Abuse; University of Pennsylvania; Japanese Circulation Society; Vanderbilt University; Alnylam Pharmaceuticals; Massachusetts General Hospital; Broad Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; U.S. Department of Health and Human Services","keywords":"Biology; Internal medicine; Endocrinology; Allele; Exome; Genome-wide association study; Coronary artery disease; High-density lipoprotein; Cholesterol; Lipolysis; Type 2 diabetes; Genotyping; Single-nucleotide polymorphism; Lipoprotein; Genetics; Exome sequencing; Diabetes mellitus; Genotype; Gene; Medicine; Adipose tissue; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000873878,0.0005342306,0.0006560895,0.000673756,0.0007224597,0.0008076598,0.000452983,0.0009895916,0.002325281],"category_scores_gemma":[0.001958251,0.0004917322,0.000806626,0.0017514,0.0003312404,0.0004232613,0.0006717741,0.0006552649,0.000460074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002654914,"about_ca_system_score_gemma":0.0002758989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009367976,"about_ca_topic_score_gemma":0.01132039,"domain_scores_codex":[0.9991493,0.0001876809,0.00009218702,0.0003736041,0.00009913671,0.00009812199],"domain_scores_gemma":[0.9993729,0.000192939,0.0001370676,0.0001499288,0.00005628086,0.00009087632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002142397,0.00008750043,0.9764583,0.00006609069,0.001849393,0.001208657,0.0002871958,0.0003828123,0.00930317,0.0002445074,0.002361575,0.005608432],"study_design_scores_gemma":[0.0001128885,0.0000804586,0.9949594,0.0000125623,0.0007269738,0.0009371527,0.0001125112,0.0005178601,0.000473297,0.0001879038,0.001864474,0.00001449892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942457,0.0006055805,0.0003998252,0.0001430892,0.00002240762,0.000009011255,0.003964799,0.00002614161,0.0005834365],"genre_scores_gemma":[0.9964682,0.0001898119,0.0003157396,0.00008907492,0.00001762793,0.00001234569,0.002067612,0.00001857302,0.0008210206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009367976,"threshold_uncertainty_score":0.01862687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307542389857536,"score_gpt":0.2913203457382377,"score_spread":0.2782449218396624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}