{"id":"W2767101040","doi":"10.1038/cdd.2017.168","title":"Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice","year":2017,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; National Health and Medical Research Council; Peter MacCallum Cancer Centre; McMaster University","keywords":"Bioenergetics; Mitochondrion; Lipid metabolism; Endocrinology; Apoptosis; Internal medicine; Insulin; Programmed cell death; Lipid oxidation; Metabolism; Cell biology; Reactive oxygen species; Phenotype; Biology; Chemistry; Biochemistry; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006971044,0.00009100867,0.0001136906,0.00003782219,0.00009994426,0.00005624882,0.00003771505,0.00009885724,0.000001797722],"category_scores_gemma":[0.00006084746,0.00008680009,0.00001727608,0.000008953026,0.00008001299,0.00002119738,0.00007797176,0.00003622397,4.635127e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003425436,"about_ca_system_score_gemma":0.00001444419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294667,"about_ca_topic_score_gemma":0.0002846166,"domain_scores_codex":[0.999476,0.00004310083,0.0001320236,0.0002213769,0.00004443454,0.00008304035],"domain_scores_gemma":[0.9996351,0.00001392137,0.0001340183,0.0001209888,0.00005050237,0.00004549707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001479008,0.00004384054,0.1761679,0.00004164936,0.00001075697,6.54173e-7,0.00003763261,3.455066e-7,0.8218197,0.00001162425,0.000008465798,0.001709561],"study_design_scores_gemma":[0.0004597866,0.00007102552,0.5452258,0.0000154868,0.00001823315,0.000003145025,0.00001260745,0.0001183907,0.4539579,0.00005042033,0.000008251803,0.0000588961],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986644,0.0008139379,0.0002501112,0.00002296394,0.00007542818,0.0001214851,0.00001892063,0.000002613211,0.00003012616],"genre_scores_gemma":[0.997383,0.002208246,0.0001169539,0.00001663265,0.00008846278,0.000004134917,0.000147881,0.000004159679,0.0000305407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3690579,"threshold_uncertainty_score":0.3539605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107534950314182,"score_gpt":0.2348931581461178,"score_spread":0.2241396631146996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}