{"id":"W2767130856","doi":"10.3390/cancers9110148","title":"Novel Molecular Challenges in Targeting Anaplastic Lymphoma Kinase in ALK-Expressing Human Cancers","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Anaplastic lymphoma kinase; Cancer research; Anaplastic large-cell lymphoma; Crizotinib; Tyrosine kinase; Receptor tyrosine kinase; Lymphoma; Biology; Receptor Protein-Tyrosine Kinases; Kinase; Medicine; Signal transduction; Immunology; Lung cancer; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000476913,0.0005220183,0.0009313098,0.001604161,0.0002485733,0.0008835909,0.0005652078,0.0008897201,0.003450935],"category_scores_gemma":[0.000507025,0.0002165523,0.0004599338,0.001298052,0.0003243437,0.001418124,0.0005781843,0.001746349,0.001739008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000533524,"about_ca_system_score_gemma":0.0009248278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007304529,"about_ca_topic_score_gemma":0.001585484,"domain_scores_codex":[0.9998529,0.00002526067,0.00002238107,0.00002183478,0.00006178694,0.00001579139],"domain_scores_gemma":[0.9998094,0.00007811259,0.0000286525,0.000005419556,0.00006167252,0.00001681968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006853323,0.00008123718,0.0001738775,0.02285504,0.0000800319,0.0003747601,0.0001247681,0.0005198047,0.005214243,0.009090546,0.03493234,0.9264848],"study_design_scores_gemma":[0.000008097043,0.00006378756,0.000293946,0.001930546,0.0000621097,0.001047298,0.00005692487,0.00007178739,0.0006349896,0.001852862,0.9939662,0.00001142564],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001918314,0.9976231,0.0001870438,0.0004584835,0.0002251937,0.00000535815,0.00002085879,0.000008584188,0.001279585],"genre_scores_gemma":[0.0007014585,0.9980458,0.0002042637,0.0002202633,0.0001391644,0.000005981145,0.00002908575,0.000001471898,0.0006525016],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003450935,"threshold_uncertainty_score":0.01154453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310413050659529,"score_gpt":0.3806893129005836,"score_spread":0.2496480078346307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}