{"id":"W2767146486","doi":"10.1016/j.cmet.2018.04.013","title":"The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes","year":2018,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"H2020 European Research Council; Ministerio de Economía y Competitividad; Agència de Gestió d'Ajuts Universitaris i de Recerca; Juvenile Diabetes Research Foundation International; Max-Planck-Gesellschaft; Bundesministerium für Bildung und Forschung","keywords":"Chromatin; PRC2; Epigenome; Polycomb-group proteins; Biology; Ectopic expression; Cell biology; Genetics; DNA methylation; Cancer research; EZH2; Transcription factor; Gene; Repressor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105801,0.0002510901,0.0002094317,0.0002842929,0.0001080574,0.0006130377,0.0001599568,0.0001745432,0.000479616],"category_scores_gemma":[0.0002801843,0.0001823379,0.0001320407,0.0002315676,0.0002947811,0.0003041757,0.0004767358,0.0003008595,0.0001301328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537256,"about_ca_system_score_gemma":0.0001268481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003624078,"about_ca_topic_score_gemma":0.0008329378,"domain_scores_codex":[0.999881,0.00001609192,0.000006502214,0.00004514921,0.00002670424,0.00002450783],"domain_scores_gemma":[0.999842,0.00002100725,0.0000658366,0.00002800105,0.00001228197,0.00003088917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190114,0.000009837919,0.02711883,0.00002482068,0.00004053564,0.0001196845,0.0000618232,0.0003266769,0.9634238,0.0004641479,0.00006591775,0.008153849],"study_design_scores_gemma":[0.00001617314,0.0001989875,0.5809848,0.00001736548,0.00008691961,0.001309521,0.0002174528,0.005289202,0.4065587,0.002252747,0.003043551,0.0000245596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904066,0.001392529,0.006611669,0.00009580745,0.000009861242,0.000006201195,0.0003975108,0.0001021642,0.0009776102],"genre_scores_gemma":[0.9976695,0.000567208,0.001153797,0.00003723647,0.000005525773,0.000003162961,0.0001801065,0.00001339502,0.0003699564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006130377,"threshold_uncertainty_score":0.001604438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006654315591094274,"score_gpt":0.2072480422117901,"score_spread":0.2005937266206958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}