{"id":"W2767146486","doi":"10.1016/j.cmet.2018.04.013","title":"The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes","year":2018,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"H2020 European Research Council; Ministerio de Economía y Competitividad; Agència de Gestió d'Ajuts Universitaris i de Recerca; Juvenile Diabetes Research Foundation International; Max-Planck-Gesellschaft; Bundesministerium für Bildung und Forschung","keywords":"Chromatin; PRC2; Epigenome; Polycomb-group proteins; Biology; Ectopic expression; Cell biology; Genetics; DNA methylation; Cancer research; EZH2; Transcription factor; Gene; Repressor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003328831,0.0001999898,0.0003514189,0.00008619763,0.0004268658,0.0000889127,0.00009115416,0.00009393411,0.0004108417],"category_scores_gemma":[0.0001599301,0.0001285099,0.00008444282,0.000142448,0.0002282263,0.00008256738,0.00004737877,0.0001507515,0.0003284873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002163159,"about_ca_system_score_gemma":0.00005719384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001534333,"about_ca_topic_score_gemma":0.000003046759,"domain_scores_codex":[0.9986481,0.0000866987,0.0003123391,0.0002940203,0.0002727673,0.000386047],"domain_scores_gemma":[0.9987733,0.0002437272,0.000130692,0.0003923922,0.0002277787,0.0002321071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003778198,0.0004852864,0.1625828,0.0001737076,0.0003572041,0.000004226767,0.0008765887,9.784472e-7,0.8009896,0.003122484,0.01811931,0.01291006],"study_design_scores_gemma":[0.005966912,0.0003029667,0.4227116,0.00002162239,0.0007765538,0.000003585603,0.0003599925,0.000297841,0.3158917,0.001633284,0.2517215,0.0003125155],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661617,0.01296707,0.0002910244,0.0007591132,0.001648109,0.000398747,0.000008388516,0.00009241307,0.01767347],"genre_scores_gemma":[0.9808812,0.0005452686,0.000144094,0.001230759,0.001079402,0.00004643937,0.00001575988,0.00002718077,0.01602988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4850979,"threshold_uncertainty_score":0.524048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006654315591094274,"score_gpt":0.2072480422117901,"score_spread":0.2005937266206958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}