{"id":"W2767151183","doi":"10.3899/jrheum.161238","title":"CNTO6785, a Fully Human Antiinterleukin 17 Monoclonal Antibody, in Patients with Rheumatoid Arthritis with Inadequate Response to Methotrexate: A Randomized, Placebo-controlled, Phase II, Dose-ranging Study","year":2017,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Amgen","keywords":"Medicine; Dose-ranging study; Rheumatoid arthritis; Placebo; Methotrexate; Internal medicine; Clinical endpoint; Adverse effect; Rheumatology; Pharmacokinetics; Gastroenterology; Randomized controlled trial; Phases of clinical research; Surgery; Clinical trial; Pathology; Double blind","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001583833,0.001017575,0.002140146,0.0004048155,0.0003188085,0.0005637629,0.0006726948,0.001141054,0.002147845],"category_scores_gemma":[0.001075522,0.0005874576,0.0008423128,0.0003612557,0.0008375169,0.000707962,0.0002445119,0.001579527,0.0004450761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003832755,"about_ca_system_score_gemma":0.0008364429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004138225,"about_ca_topic_score_gemma":0.001082223,"domain_scores_codex":[0.9995255,0.000232906,0.00004158765,0.00006525769,0.00006793936,0.00006677657],"domain_scores_gemma":[0.9991038,0.0002504315,0.0002340147,0.00005092984,0.00007399021,0.0002868001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9275699,0.02065886,0.002805154,0.0008725157,0.0007538866,0.0001365788,0.00007981325,0.0004044162,0.01838577,0.00006677295,0.0004576458,0.02780879],"study_design_scores_gemma":[0.7306879,0.2621988,0.004690287,0.00002493671,0.0003669452,0.0001028292,0.0000211745,0.0003747429,0.001032087,0.00003614204,0.0004514291,0.00001276706],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948601,0.002748251,0.0003374229,0.0001519439,0.0001390632,0.001120405,0.0001741454,0.0000407734,0.0004278378],"genre_scores_gemma":[0.9949237,0.001732485,0.0008621729,0.0004430069,0.0003014712,0.0008297646,0.0002985304,0.000008893987,0.0005999847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002147845,"threshold_uncertainty_score":0.008376181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177449892360593,"score_gpt":0.2799073730707837,"score_spread":0.2681328741471778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}