{"id":"W2767171862","doi":"10.1021/acs.joc.7b02218","title":"Observation of a Tricyclic[4.1.0.0<sup>2,4</sup>]heptane During a Michael Addition-Ring Closure Reaction and a Computational Study on Its Mechanism of Formation","year":2017,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; FP7 People: Marie-Curie Actions; Canadian Institutes of Health Research","keywords":"Cyclopropanation; Chemistry; Ylide; Michael reaction; Bicyclic molecule; Cyclopropane; Moiety; Medicinal chemistry; Stereochemistry; Ring (chemistry); Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000440102,0.000190071,0.0003468187,0.00006521672,0.0002859458,0.00003497527,0.0003412036,0.0001292746,0.0001986975],"category_scores_gemma":[0.0003758522,0.0001592614,0.0001005561,0.00009501206,0.00004503185,0.0004166757,0.00008992591,0.0004033874,0.000002231805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772442,"about_ca_system_score_gemma":0.00008260934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008668277,"about_ca_topic_score_gemma":0.000002025104,"domain_scores_codex":[0.9982749,0.00003461548,0.000791018,0.0001445844,0.0006137007,0.0001412418],"domain_scores_gemma":[0.9966598,0.0001462701,0.002266656,0.0003825688,0.0004763878,0.00006838355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003334467,0.0002163054,0.0003260481,0.0004400246,0.0001203727,0.000008314941,0.002260589,0.0002424878,0.9956324,0.00002127067,0.000005830297,0.0003929517],"study_design_scores_gemma":[0.002466882,0.0001132668,0.006147429,0.0003544497,0.00021715,0.0007165673,0.007919019,0.001144515,0.9804235,0.0003485084,0.000009267927,0.0001394654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989356,0.00006400362,0.0003612432,0.000115561,0.00004114951,0.0001304666,0.00002572436,0.0000160932,0.0003101077],"genre_scores_gemma":[0.9993382,0.00007645342,0.0002002625,0.000005157786,0.0002133046,0.000003607134,0.00001491752,0.0000276036,0.0001205173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01520888,"threshold_uncertainty_score":0.6494493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02773118816832543,"score_gpt":0.2536681862033238,"score_spread":0.2259369980349984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}