{"id":"W2767235977","doi":"10.1093/neuonc/nox168.752","title":"PDCT-08. TRAMETINIB AND DABRAFENIB FOR REFRACTORY/INOPERABLE PEDIATRIC LOW GRADE GLIOMAS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Dabrafenib; Trametinib; Ganglioglioma; Medicine; Pilocytic astrocytoma; Oncology; Refractory (planetary science); Glioma; Internal medicine; Progressive disease; Anaplastic astrocytoma; Astrocytoma; Chemotherapy; Cancer research; Epilepsy; Cancer; MAPK/ERK pathway; Vemurafenib; Metastatic melanoma; Kinase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055082,0.0002475354,0.0005953352,0.0001723105,0.0004296975,0.0000745992,0.0001851695,0.0002516707,0.00008454126],"category_scores_gemma":[0.0006971171,0.0002009444,0.0001445471,0.00007936601,0.0001444782,0.0001315697,0.00009331469,0.0002354345,0.00005280144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001046919,"about_ca_system_score_gemma":0.0001889446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004711268,"about_ca_topic_score_gemma":0.00003959278,"domain_scores_codex":[0.9984285,0.00007390095,0.0003147745,0.0005512269,0.0001692386,0.0004623594],"domain_scores_gemma":[0.9980186,0.0006483528,0.0002501373,0.0006853665,0.00009444551,0.0003030729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001963604,0.009175879,0.3368396,0.0006817149,0.0004173514,0.00412283,0.0009506461,0.000008470431,0.4250111,0.002219293,0.06782521,0.1507843],"study_design_scores_gemma":[0.02586502,0.008240422,0.1170588,0.00003539935,0.001130906,0.0006599997,0.00009843861,0.0002301492,0.04987787,0.0004021203,0.7959549,0.0004460159],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855604,0.0009638778,0.00000927655,0.009043786,0.0008381232,0.001048776,0.00003358559,0.00006509182,0.002437113],"genre_scores_gemma":[0.9958172,0.0008476791,0.0009067286,0.001213412,0.0007272363,0.0002954562,0.00002417881,0.00004847074,0.0001196447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7281297,"threshold_uncertainty_score":0.8194275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633574242593025,"score_gpt":0.3325535657413391,"score_spread":0.2962178233154089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}