{"id":"W2767235977","doi":"10.1093/neuonc/nox168.752","title":"PDCT-08. TRAMETINIB AND DABRAFENIB FOR REFRACTORY/INOPERABLE PEDIATRIC LOW GRADE GLIOMAS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Dabrafenib; Trametinib; Ganglioglioma; Medicine; Pilocytic astrocytoma; Oncology; Refractory (planetary science); Glioma; Internal medicine; Progressive disease; Anaplastic astrocytoma; Astrocytoma; Chemotherapy; Cancer research; Epilepsy; Cancer; MAPK/ERK pathway; Vemurafenib; Metastatic melanoma; Kinase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421858,0.0002329072,0.0002698093,0.0003058743,0.0001710462,0.000270651,0.0002266651,0.0003165341,0.002968737],"category_scores_gemma":[0.0002187166,0.00006837414,0.0002330685,0.0002992723,0.0001346968,0.0001850286,0.000195022,0.0006294738,0.001044712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004165425,"about_ca_system_score_gemma":0.000615444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072239,"about_ca_topic_score_gemma":0.003801299,"domain_scores_codex":[0.9999123,0.00001833924,0.00001146879,0.00001424947,0.0000199743,0.0000236539],"domain_scores_gemma":[0.9998772,0.00001568706,0.00003147339,0.000007157444,0.00001053649,0.00005794653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009149602,0.0009593246,0.07254918,0.0009800367,0.0002495662,0.01509538,0.0001722003,0.00167403,0.03102748,0.001689531,0.03735983,0.8290938],"study_design_scores_gemma":[0.008124308,0.02256296,0.3148667,0.0006338151,0.0003997814,0.1443415,0.0001772135,0.004007038,0.04857612,0.001202531,0.4550184,0.00008967079],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9001014,0.04339705,0.002116059,0.002113241,0.0002756572,0.000386913,0.003896577,0.0004858025,0.04722724],"genre_scores_gemma":[0.973949,0.008664909,0.002657871,0.0009056094,0.0001068933,0.0002043916,0.004326891,0.00004461946,0.009139796],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002968737,"threshold_uncertainty_score":0.009931386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633574242593025,"score_gpt":0.3325535657413391,"score_spread":0.2962178233154089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}