{"id":"W2767256130","doi":"10.3389/fnmol.2017.00361","title":"Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT","year":2017,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Transporter; Amyloid (mycology); Antibody; Chemistry; Terminal (telecommunication); Amyloid β; Biochemistry; Amyloid precursor protein; P3 peptide; Choline; Neuroscience; Cell biology; Biophysics; Biology; Alzheimer's disease; Disease; Medicine; Immunology; Gene; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817795,0.0006732002,0.000561941,0.0003197564,0.0002157144,0.0002995167,0.0004896382,0.0005104613,0.001235252],"category_scores_gemma":[0.0001828984,0.0002453896,0.0004951516,0.0002155682,0.0002403968,0.000249437,0.0001805231,0.001076729,0.0005694409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916753,"about_ca_system_score_gemma":0.0003424366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009506462,"about_ca_topic_score_gemma":0.001147511,"domain_scores_codex":[0.9997103,0.00005357547,0.00004598558,0.00004195573,0.00005892386,0.00008935136],"domain_scores_gemma":[0.9998083,0.00004717654,0.00004452363,0.0000231239,0.00003647252,0.00004038631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000313795,0.0002443195,0.00007582036,0.00007269951,0.00001896239,0.00006352336,0.00001777661,0.00005278118,0.9980316,0.00008511901,0.00005949602,0.0009642048],"study_design_scores_gemma":[0.0001408867,0.001758506,0.002362144,0.00001171735,0.00004374062,0.0003260559,0.00001661223,0.0008921814,0.9915094,0.00003545336,0.002897479,0.000005789655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922481,0.003246586,0.001843256,0.0001579813,0.0001220047,0.00009993761,0.0003023005,0.0001102101,0.001869739],"genre_scores_gemma":[0.9899486,0.003704606,0.002356539,0.00007959558,0.00004689919,0.0001341763,0.0007641785,0.00002991645,0.002935556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235252,"threshold_uncertainty_score":0.00413233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561690652414707,"score_gpt":0.2936856560608323,"score_spread":0.2780687495366853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}