{"id":"W2767273210","doi":"10.1093/hmg/ddx394","title":"HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Huntington's disease; Phenotype; Astrocyte; In vivo; Mitochondrion; Genetics; Function (biology); Disease; Cell biology; Neuroscience; Gene; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196867,0.0003573372,0.0003531503,0.0003115566,0.0003213688,0.0003835337,0.0003205332,0.0003850056,0.001460207],"category_scores_gemma":[0.0002315625,0.0002228031,0.0002084154,0.0002531878,0.0002934291,0.000183326,0.0003489263,0.0005582024,0.0007082225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003959704,"about_ca_system_score_gemma":0.0003307932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001119543,"about_ca_topic_score_gemma":0.002258331,"domain_scores_codex":[0.9997072,0.00004357237,0.00004044678,0.00006212711,0.00008964341,0.00005707839],"domain_scores_gemma":[0.9995591,0.00006621049,0.0001404644,0.00008008598,0.00004584063,0.0001082306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473509,0.00002652355,0.0001986648,0.00001889298,0.000004991848,0.00004958197,0.00001106839,0.00003830207,0.9989831,0.0000687381,0.00003559297,0.0004171989],"study_design_scores_gemma":[0.0000263898,0.000171081,0.006223399,0.000006907011,0.00001809817,0.000390155,0.00003524772,0.0008976599,0.9892938,0.00005780799,0.002873832,0.000005656704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934076,0.0009622367,0.002831607,0.0001597626,0.00004207242,0.00003666474,0.001159461,0.0001194159,0.001281247],"genre_scores_gemma":[0.9913815,0.000664963,0.002738076,0.00005449023,0.00001136262,0.00006965607,0.001478538,0.00009870755,0.003502784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460207,"threshold_uncertainty_score":0.004884839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341367683743688,"score_gpt":0.2916470319250913,"score_spread":0.2682333550876544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}