{"id":"W2767273210","doi":"10.1093/hmg/ddx394","title":"HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Huntington's disease; Phenotype; Astrocyte; In vivo; Mitochondrion; Genetics; Function (biology); Disease; Cell biology; Neuroscience; Gene; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004669009,0.0002216931,0.0001695079,0.00009154114,0.000594686,0.0003845321,0.0003659317,0.00005366036,0.0000432692],"category_scores_gemma":[0.000364177,0.0002415754,0.0000855023,0.00004702962,0.0002965012,0.0001034786,0.0001844953,0.00008325255,0.000006156333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001242302,"about_ca_system_score_gemma":0.00005820804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001294267,"about_ca_topic_score_gemma":0.00003341349,"domain_scores_codex":[0.9983698,0.00008881267,0.0002386087,0.0006862648,0.0002883706,0.0003281463],"domain_scores_gemma":[0.9989671,0.0000356416,0.0001799305,0.0005856802,0.00006120581,0.000170507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001298504,0.00006613114,0.007105321,0.00003159712,0.000005273679,0.000006729581,0.00006408874,0.0004767998,0.9909714,0.0007068377,0.000118583,0.0003174302],"study_design_scores_gemma":[0.001092947,0.0001471491,0.1106544,0.00002016209,0.00006537768,4.131375e-7,0.00001013326,0.0006173892,0.8825879,0.003954047,0.0006164106,0.0002336844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957358,0.0001769698,0.002814991,0.0001334691,0.0003714224,0.0005692789,0.00006041575,0.0000245594,0.0001130871],"genre_scores_gemma":[0.9983724,0.00002963905,0.0006135238,0.0005267753,0.0002089687,0.00007908959,0.00000404765,0.00003686153,0.0001287045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1083834,"threshold_uncertainty_score":0.9851161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341367683743688,"score_gpt":0.2916470319250913,"score_spread":0.2682333550876544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}