{"id":"W2767327745","doi":"10.1016/j.jid.2017.10.028","title":"Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma","year":2017,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Cutaneous lymphoproliferative disorders research","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Hearst Foundations; National Cancer Institute; National Institute of General Medical Sciences; School of Medicine, New York University; National Institutes of Health; Kræftens Bekæmpelse; York University; Cutaneous Lymphoma Foundation; Novo Nordisk Fonden; Patton Charitable Foundation; Concern Foundation","keywords":"Biology; Lymphoma; Cutaneous T-cell lymphoma; Transcriptome; Mycosis fungoides; Cytokine; Cancer research; Pathogenesis; Malignancy; T-cell receptor; T cell; Immunology; Disease; Immune system; Medicine; Gene; Pathology; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004190321,0.0001724884,0.000845754,0.0003180552,0.0001083038,0.00002297657,0.0003403256,0.0001491659,0.00003042158],"category_scores_gemma":[0.001317039,0.0001180405,0.0001306695,0.000150608,0.001445216,0.0001057088,0.00006956755,0.0001913704,9.555654e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005273549,"about_ca_system_score_gemma":0.0005162189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009413354,"about_ca_topic_score_gemma":0.0000314041,"domain_scores_codex":[0.9979064,0.0004472219,0.0008516817,0.0001513641,0.0004027108,0.0002406418],"domain_scores_gemma":[0.9973677,0.0004319983,0.00118054,0.0003019931,0.0005885811,0.0001291467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001529156,0.0003290681,0.02380485,0.0001513327,0.0001284086,0.001240757,0.003123403,0.0000120447,0.9683842,0.0000980681,0.00005468826,0.001143986],"study_design_scores_gemma":[0.004979932,0.0008047016,0.03357548,0.0002062776,0.0001190094,0.02605604,0.002418556,0.0003722409,0.9299033,0.001356691,0.0001048687,0.0001029411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972765,0.0006635409,0.000006536126,0.001351505,0.00004184599,0.0002892387,0.00001831371,0.000002342004,0.0003501524],"genre_scores_gemma":[0.9991109,0.0001522629,0.0005588806,0.00009836866,0.00004169493,0.000003660803,0.000003987881,0.0000167326,0.00001351449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03848097,"threshold_uncertainty_score":0.5324959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060224989237652,"score_gpt":0.2803426674434915,"score_spread":0.259740417551115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}