{"id":"W2767341919","doi":"10.1016/j.bbagen.2017.11.009","title":"FTIR study of secondary structure changes in Epidermal Growth Factor by gold nanoparticle conjugation","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Government of Canada","keywords":"Bifunctional; Epidermal growth factor; Nanoparticle; Colloidal gold; Fourier transform infrared spectroscopy; Protein secondary structure; Chemistry; Biophysics; Nanotechnology; Crystallography; Materials science; Biochemistry; Chemical engineering; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006537924,0.0003451476,0.0004173913,0.00004341037,0.0002322463,0.0001159706,0.0006790461,0.0001978483,0.0001959388],"category_scores_gemma":[0.00007542036,0.0003397962,0.00009027292,0.0001287478,0.0001668302,0.0002234287,0.0002282993,0.0003340406,0.000006201825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005980363,"about_ca_system_score_gemma":0.00006822835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000448811,"about_ca_topic_score_gemma":0.0003016017,"domain_scores_codex":[0.9982588,0.00004606052,0.000404728,0.0006112508,0.000279196,0.000399971],"domain_scores_gemma":[0.9982693,0.00007394984,0.0005031243,0.0009315835,0.00007753927,0.0001444734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007288264,0.000788139,0.0005867565,0.0001021171,0.00006021348,0.000003385625,0.0006886793,9.809545e-7,0.9965708,0.00003804047,0.0008254715,0.00026259],"study_design_scores_gemma":[0.001430406,0.00010098,0.02379348,0.00003248072,0.00003726634,0.0000030634,0.0002033566,0.00006256495,0.9737228,0.000158153,0.00009942862,0.0003559864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968116,0.00002528299,1.626754e-7,0.001246541,0.00006227878,0.0002667957,0.0007722898,0.00006178198,0.0007533082],"genre_scores_gemma":[0.9986769,0.00002294564,0.00004964248,0.0001228753,0.0002669549,0.00007447456,0.0002680488,0.00004089114,0.0004772804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02320672,"threshold_uncertainty_score":0.9999054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678483428202114,"score_gpt":0.2661511580524475,"score_spread":0.2493663237704264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}