{"id":"W2767344312","doi":"10.1016/j.cbpb.2017.11.001","title":"Sensing and responding to energetic stress: Evolution of the AMPK network","year":2017,"lang":"en","type":"review","venue":"Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brandon University; Queen's University; University of Waterloo","funders":"","keywords":"Subfunctionalization; AMPK; Biology; Effector; Protein kinase A; Gene; Function (biology); Genome; Mechanism (biology); Computational biology; Phosphorylation; Genetics; Evolutionary biology; Cell biology; Gene family","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006507837,0.0008687055,0.001166847,0.001480244,0.0002894783,0.00160273,0.001130096,0.001321443,0.0020422],"category_scores_gemma":[0.0005902928,0.0003595573,0.0003427138,0.002326728,0.001247959,0.002475021,0.001126632,0.002143545,0.001362299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071215,"about_ca_system_score_gemma":0.00132003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006886284,"about_ca_topic_score_gemma":0.001123855,"domain_scores_codex":[0.999851,0.00001896688,0.00001637247,0.00004787035,0.00004488794,0.00002084483],"domain_scores_gemma":[0.9997165,0.0001029373,0.00004858558,0.00001680082,0.0000739741,0.00004116058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001577527,0.00002778914,0.0003896278,0.007407511,0.00009888202,0.0002128582,0.0000792292,0.0009778301,0.007400143,0.01829038,0.01633746,0.9486206],"study_design_scores_gemma":[0.00001553283,0.00003401716,0.001306274,0.001457484,0.00008714158,0.0007555192,0.00008277944,0.0001805787,0.001512319,0.01143851,0.9831007,0.00002937481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002714721,0.9974063,0.0003806923,0.000611314,0.000278637,0.00000187328,0.00001977922,0.000009782986,0.001020048],"genre_scores_gemma":[0.001589549,0.9970938,0.0002996916,0.0002423089,0.0002539107,0.000003221562,0.00003592444,0.000002509249,0.0004790607],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0020422,"threshold_uncertainty_score":0.007772267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764423365539658,"score_gpt":0.3452423759012611,"score_spread":0.3075981422458645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}