{"id":"W2767357331","doi":"10.1093/neuonc/nox168.002","title":"ACTR-02. DCC-2618, A NOVEL pan-KIT AND PDGFRa KINASE SWITCH CONTROL INHIBITOR, SHOWS ENCOURAGING SIGNAL IN A PATIENT (PT) WITH GLIOBLASTOMA (GBM)","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"PDGFRA; Temozolomide; Medicine; Cancer research; Kinase; Internal medicine; Glioma; Oncology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655988,0.0003317322,0.0005244691,0.000219885,0.0001321454,0.0003064137,0.0002631563,0.0003169632,0.002535758],"category_scores_gemma":[0.0001157795,0.0001409186,0.0002209067,0.0002120367,0.0002286124,0.0001226603,0.000122046,0.0007938981,0.0007286213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003703559,"about_ca_system_score_gemma":0.0003723953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008867651,"about_ca_topic_score_gemma":0.002864267,"domain_scores_codex":[0.9999039,0.00001944931,0.000006575373,0.00002164907,0.00002104402,0.00002726916],"domain_scores_gemma":[0.9999285,0.000007433852,0.00001479409,0.00000739114,0.000005958282,0.0000359946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.04846589,0.01184533,0.0168466,0.0009252821,0.0003071993,0.002805675,0.0002570293,0.00334066,0.5892521,0.0008725202,0.01412325,0.3109584],"study_design_scores_gemma":[0.04293031,0.3010816,0.1282804,0.00009593604,0.0007668464,0.02187878,0.0001576455,0.007548213,0.3965565,0.0004134231,0.1001885,0.0001018294],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884865,0.002249671,0.0008411281,0.0002200207,0.00005207784,0.0006075311,0.0009812416,0.0001799598,0.006381867],"genre_scores_gemma":[0.9896354,0.001547947,0.001093743,0.0002459675,0.00002997192,0.0003340143,0.001926297,0.00002081494,0.005165814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002535758,"threshold_uncertainty_score":0.008482993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390696105435018,"score_gpt":0.2680006799037273,"score_spread":0.2540937188493771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}