{"id":"W2767364014","doi":"10.1038/s41598-017-15630-z","title":"Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; University Health Network; Mount Sinai Hospital; University of Saskatchewan; Université Laval; McMaster University; Public Health Ontario; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; Council of Ontario Universities","keywords":"Humanized mouse; Biology; Viral load; Immunology; Inflammation; Virology; Haematopoiesis; Spleen; Stem cell; Human immunodeficiency virus (HIV); Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003871344,0.0005081159,0.0003376954,0.0007054607,0.0002099784,0.0005305156,0.0002420184,0.0006089552,0.002723468],"category_scores_gemma":[0.0001928876,0.0003546885,0.0002503397,0.0001634186,0.000358328,0.0002981477,0.0002794775,0.001241554,0.0004628492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426679,"about_ca_system_score_gemma":0.0001320686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004030704,"about_ca_topic_score_gemma":0.0003740758,"domain_scores_codex":[0.9995244,0.00009228479,0.00003515674,0.0001414415,0.00009861191,0.0001080896],"domain_scores_gemma":[0.9997067,0.00004609862,0.00009328924,0.00005040776,0.00002179094,0.00008168959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003668421,0.0001811204,0.0004514488,0.00002193132,0.000004544763,0.00003005308,0.00003314112,0.00004457402,0.9978486,0.00007202575,0.00003687912,0.0009088707],"study_design_scores_gemma":[0.00008829638,0.003639695,0.0138317,0.00002334758,0.00003291729,0.0008458691,0.00009060033,0.001791456,0.9773502,0.0001299824,0.002164033,0.00001180272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994459,0.000917909,0.002319708,0.00009965835,0.00002303249,0.00008760665,0.0007356392,0.00011545,0.001242001],"genre_scores_gemma":[0.9928117,0.0004095194,0.002406301,0.000079711,0.00001694223,0.000160917,0.0006486264,0.0000319639,0.00343434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002723468,"threshold_uncertainty_score":0.009110868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751196900973963,"score_gpt":0.2891535525728462,"score_spread":0.2716415835631066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}