{"id":"W2767364701","doi":"10.1093/neuonc/nox168.116","title":"ATIM-21. INTRAVENOUS DELIVERY OF TOCA 511 IN PATIENTS WITH HIGH GRADE GLIOMA RESULTS IN QUANTIFIABLE EXPRESSION OF CYTOSINE DEAMINASE IN TUMOR TISSUE","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute","funders":"","keywords":"Cytosine deaminase; Molecular biology; Immunohistochemistry; Biology; Pathology; Cancer research; Genetic enhancement; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136416,0.000206797,0.0003736492,0.0001431095,0.0001346559,0.0002122945,0.0001028516,0.0002416494,0.0008716883],"category_scores_gemma":[0.0001604405,0.00009097686,0.0001157223,0.0001723994,0.0001530578,0.000118382,0.00006963842,0.000310334,0.0002658237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004651077,"about_ca_system_score_gemma":0.0002448014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008771569,"about_ca_topic_score_gemma":0.002161234,"domain_scores_codex":[0.9999416,0.0000117934,0.000003059598,0.00001439371,0.00001166753,0.00001738941],"domain_scores_gemma":[0.9999374,0.00001083347,0.00001568449,0.000004321065,0.000004961166,0.00002666811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03141703,0.002733609,0.1699314,0.0003784585,0.0002220334,0.004253247,0.0002336724,0.001185399,0.6035205,0.0002894647,0.00390047,0.1819347],"study_design_scores_gemma":[0.003708966,0.1213252,0.6981612,0.00004354538,0.0003964379,0.01564331,0.000154855,0.004662724,0.140761,0.0002054073,0.01489515,0.00004209629],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968106,0.0009004989,0.0003478819,0.00008863727,0.000009639803,0.00005996303,0.0001544792,0.00004752735,0.001580647],"genre_scores_gemma":[0.9985278,0.0002217351,0.0003245058,0.00005732651,0.000007858679,0.00002977545,0.0002692165,0.000004404,0.0005572881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008771569,"threshold_uncertainty_score":0.003374636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625679268987702,"score_gpt":0.2933595000695888,"score_spread":0.2771027073797118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}