{"id":"W2767372368","doi":"10.1038/s41467-017-01924-3","title":"Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Malaria Research and Control","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Canada Research Chairs; University of Toronto; Hospital for Sick Children","funders":"National Research Council Canada; Western Economic Diversification Canada; Canadian Institutes of Health Research; Hospital for Sick Children; National Institutes of Health; University of Saskatchewan; Canadian Light Source; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation","keywords":"Immunogen; Malaria vaccine; Virology; Plasmodium falciparum; Antigen; Antibody; Biology; Epitope; Malaria; Merozoite surface protein; Immunogenicity; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162227,0.0002537506,0.0001773194,0.0001147374,0.0001605086,0.000334786,0.0004275354,0.00025044,0.0009483881],"category_scores_gemma":[0.0001504281,0.0001700012,0.000194123,0.00007682265,0.0003330507,0.0003209631,0.0001889603,0.0006894748,0.0002338271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658649,"about_ca_system_score_gemma":0.000339932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000623126,"about_ca_topic_score_gemma":0.001039051,"domain_scores_codex":[0.9999087,0.0000143714,0.000005695354,0.00001902762,0.00003302616,0.000019112],"domain_scores_gemma":[0.9999316,0.00001289724,0.00002001599,0.00000738895,0.0000101306,0.00001793166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000820693,0.00003463476,0.0003087805,0.00003864645,0.000006492145,0.00008444583,0.00002574694,0.001438691,0.9932387,0.002564501,0.0001387948,0.002038382],"study_design_scores_gemma":[0.00003397846,0.000188353,0.001354296,0.000008723819,0.00001118737,0.000203677,0.00003585922,0.007598985,0.9859713,0.0005824266,0.004003234,0.00000803357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786886,0.00104719,0.01525787,0.0002055987,0.00002899336,0.0000433364,0.0001585526,0.000100209,0.004469717],"genre_scores_gemma":[0.9887659,0.0004599348,0.009515004,0.00008353841,0.000007298878,0.00002399568,0.0001935027,0.00001182122,0.0009389714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009483881,"threshold_uncertainty_score":0.00338012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03015211841294207,"score_gpt":0.3467456951347295,"score_spread":0.3165935767217874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}