{"id":"W2767385434","doi":"10.3389/fcimb.2017.00470","title":"Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells","year":2017,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Association Vaincre la Mucoviscidose; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; University of North Carolina at Chapel Hill; National Institutes of Health; Rosalind Franklin University of Medicine and Science; Université de Montréal; Louisiana State University; Cystic Fibrosis Canada; Seattle Children's Research Institute; Cystic Fibrosis Foundation Therapeutics","keywords":"Pseudomonas aeruginosa; Quorum sensing; Cell biology; Microbiology; Cystic fibrosis; Function (biology); Airway; Biology; Bacteria; Biofilm; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000244934,0.000260734,0.000380879,0.0001280546,0.0001321489,0.0003408244,0.0002330816,0.000286064,0.001157653],"category_scores_gemma":[0.0001880006,0.0001276599,0.0002700236,0.0001031891,0.0001633505,0.0001635373,0.0002161888,0.0006379976,0.000331327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001522043,"about_ca_system_score_gemma":0.0002427422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001256398,"about_ca_topic_score_gemma":0.0008718499,"domain_scores_codex":[0.9997475,0.00006036534,0.00002705994,0.00004159855,0.00006864266,0.00005482689],"domain_scores_gemma":[0.9998605,0.00004255745,0.00002266888,0.00002769657,0.00002155222,0.0000249352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091274,0.00005668421,0.00007522964,0.00002790532,0.000002812141,0.0000289346,0.00001651854,0.00002923858,0.9985994,0.000030389,0.00003445624,0.0009893385],"study_design_scores_gemma":[0.00002502944,0.001232298,0.004486399,0.000007128248,0.00001083522,0.0001695754,0.00004036121,0.0006011372,0.9918794,0.00001840632,0.001524918,0.000004337795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968625,0.001354037,0.0006858801,0.0001295885,0.00003178994,0.00002652524,0.0001871964,0.00004664805,0.0006758278],"genre_scores_gemma":[0.9959146,0.0008576599,0.001074149,0.00006812655,0.00001743096,0.00003225001,0.0004545616,0.00001529579,0.001565992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256398,"threshold_uncertainty_score":0.003872693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043538399939742,"score_gpt":0.2773307398501639,"score_spread":0.2668953558507665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}