{"id":"W2767408185","doi":"10.1093/neuonc/nox168.268","title":"DRES-10. THE DISTINCT CYTOTOXIC MECHANISM OF DIANHYDROGALACTITOL (VAL-083) OVERCOMES CHEMORESISTANCE AND PROVIDES NEW OPPORTUNITIES FOR COMBINATION THERAPY IN THE TREATMENT OF GLIOBLASTOMA","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada); University of British Columbia","funders":"","keywords":"Temozolomide; Bevacizumab; Cancer research; DNA repair; Glioma; Medicine; Pharmacology; Chemistry; Chemotherapy; Internal medicine; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018794,0.0004739914,0.0002158444,0.0002351961,0.0001189211,0.0002562152,0.0002372307,0.0002598741,0.002754723],"category_scores_gemma":[0.00005878658,0.0001118256,0.0002604031,0.0002455057,0.0001701692,0.0001855988,0.000245099,0.0007042268,0.001084966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004207282,"about_ca_system_score_gemma":0.0002695272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006716122,"about_ca_topic_score_gemma":0.001526695,"domain_scores_codex":[0.9999454,0.000008286197,0.000003270181,0.00001208641,0.00001309203,0.00001786257],"domain_scores_gemma":[0.9999603,0.000002233868,0.000009100725,0.000002875213,0.000004871285,0.0000206479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001397399,0.0004036773,0.0009665296,0.0005139984,0.00005262666,0.000290189,0.00003492071,0.0006355708,0.8779669,0.00150158,0.003437385,0.1127991],"study_design_scores_gemma":[0.0007511283,0.005776477,0.009323894,0.00005850108,0.0001086485,0.002978844,0.0000478818,0.001522371,0.8278404,0.0005540068,0.1509945,0.00004333841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9035043,0.05780625,0.006897445,0.001655857,0.0005905115,0.0002888639,0.003481474,0.001376334,0.02439899],"genre_scores_gemma":[0.968688,0.01128323,0.004648544,0.0005379559,0.00005649519,0.0001040845,0.003613675,0.00006171758,0.01100642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002754723,"threshold_uncertainty_score":0.009215474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06082184004682845,"score_gpt":0.3227176996416961,"score_spread":0.2618958595948677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}