{"id":"W2767444421","doi":"10.1093/neuonc/nox168.956","title":"STEM-42. GENOME-WIDE CRISPR SCREENS IN BRAIN TUMOR INITIATING CELLS (BTICS) IDENTIFY POTENT SENSITIZERS OF CONVENTIONAL CHEMORADIOTHERAPY","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"CRISPR; Chemoradiotherapy; Cancer research; Genome editing; Frameshift mutation; Temozolomide; Biology; Medicine; Gene; Mutation; Cancer; Genetics; Glioma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239448,0.0005858015,0.0005887836,0.0004058658,0.0002834282,0.000543321,0.000344233,0.0005675179,0.002990586],"category_scores_gemma":[0.0002339908,0.0002377806,0.0004982706,0.0004212664,0.0003067752,0.0001287904,0.0003131572,0.0006618895,0.001009062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004466439,"about_ca_system_score_gemma":0.0003585889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286997,"about_ca_topic_score_gemma":0.002723498,"domain_scores_codex":[0.9995556,0.00005198321,0.00004745278,0.000102949,0.0001877705,0.00005422943],"domain_scores_gemma":[0.9998552,0.00003213846,0.00004050921,0.0000228951,0.00002114695,0.0000281226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004688762,0.00002554509,0.0001891049,0.00004667624,0.000009042864,0.00004366357,0.00001375959,0.0003264986,0.9970551,0.0001146005,0.0001284971,0.00200073],"study_design_scores_gemma":[0.00001619549,0.0003004807,0.002928954,0.000007766727,0.00003828164,0.0002805132,0.00002080924,0.001873046,0.9868518,0.00008268644,0.007588845,0.00001072652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9218171,0.00265463,0.04154261,0.0004743154,0.0001377255,0.0007925878,0.01934317,0.002808974,0.01042889],"genre_scores_gemma":[0.941621,0.002134157,0.02814422,0.0003090525,0.00001747294,0.0005043585,0.01391574,0.0003114331,0.0130426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002990586,"threshold_uncertainty_score":0.01000446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719811970316495,"score_gpt":0.328887365967081,"score_spread":0.3116892462639161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}