{"id":"W2767453022","doi":"10.1371/journal.pmed.1002417","title":"HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study","year":2017,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; James B. Pendleton Charitable Trust; National Institute of Allergy and Infectious Diseases; Delaney AIDS Research Enterprise; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; amfAR, The Foundation for AIDS Research; U.S. Department of Veterans Affairs","keywords":"Viremia; Medicine; Emtricitabine; Viral load; Peripheral blood mononuclear cell; Immunology; Efavirenz; Lymph node; Internal medicine; Bone marrow; Antiretroviral therapy; Antibody; Human immunodeficiency virus (HIV); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279379,0.000143437,0.0002962688,0.0001150616,0.0005724012,0.00001849771,0.0002213889,0.00007681391,0.0004302837],"category_scores_gemma":[0.0001702614,0.0001093342,0.00007082138,0.00006888048,0.0002073747,0.000413538,0.00005122622,0.0001797999,0.0002506933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004520655,"about_ca_system_score_gemma":0.00005332648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001688199,"about_ca_topic_score_gemma":0.00002850889,"domain_scores_codex":[0.9989352,0.0001503538,0.0002636982,0.000257427,0.0001481799,0.0002452069],"domain_scores_gemma":[0.9991564,0.00006261869,0.0001821364,0.0004367947,0.0001203639,0.00004167147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002700442,0.0005772826,0.8298211,0.000009321157,0.0007073937,0.00004712835,0.001912985,3.619296e-7,0.1658536,0.00001716175,0.0001557289,0.0006279881],"study_design_scores_gemma":[0.006103575,0.002869367,0.9806581,0.00007700195,0.0001119606,0.00001028595,0.0003004768,0.000004834621,0.009592301,0.00001084184,0.0001694187,0.00009188754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974587,0.0002948456,0.00001725016,0.0004792067,0.0002377414,0.0004182736,0.0000364418,0.00003878643,0.001018751],"genre_scores_gemma":[0.9975691,0.00009278728,0.00002629461,0.0000243582,0.00009911208,0.00004316776,0.0003270147,0.00001191637,0.001806285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1562613,"threshold_uncertainty_score":0.4711305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1797189351396123,"score_gpt":0.3504438181942264,"score_spread":0.1707248830546141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}