{"id":"W2767515057","doi":"10.1093/neuonc/nox168.1043","title":"TMOD-04. A COMPREHENSIVE GENOMIC LANDSCAPE OF GLIOMA SPHEROID CULTURES RECAPITULATES THE HETEROGENEITY OF GLIOBLASTOMA AND IDENTIFIES DNA METHYLATION PREDICTORS OF RADIOTHERAPY RESPONSE","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"DNA methylation; Methylation; Glioma; Biology; Cancer research; Radiation therapy; CpG site; Molecular biology; Oncology; Genetics; Gene; Internal medicine; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396407,0.0002807664,0.000387225,0.0003768636,0.0002067388,0.0003014587,0.0002083951,0.0002200971,0.001744832],"category_scores_gemma":[0.0001409109,0.0001445709,0.0002361383,0.00050689,0.000192383,0.0001112009,0.0001923082,0.0003770149,0.0004338854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000337862,"about_ca_system_score_gemma":0.0002843276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002012653,"about_ca_topic_score_gemma":0.004014712,"domain_scores_codex":[0.9998492,0.00001585891,0.00001429369,0.0000478636,0.00004769738,0.00002507171],"domain_scores_gemma":[0.9999366,0.000008609635,0.00001276435,0.00001596622,0.000009247779,0.00001676717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002452416,0.00005460789,0.005215231,0.00006317179,0.00002261847,0.00005762421,0.0000535431,0.0005072737,0.9879071,0.0001007071,0.0004668988,0.005306141],"study_design_scores_gemma":[0.00006585702,0.001042773,0.06906468,0.000007349835,0.00008531371,0.000863106,0.0001077511,0.004594565,0.9117535,0.0001437978,0.01225533,0.00001599377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840447,0.0004336887,0.005203935,0.00006424794,0.00001836015,0.0001003143,0.008178835,0.000242602,0.001713296],"genre_scores_gemma":[0.9480485,0.000541803,0.01192698,0.0001099166,0.000006314276,0.0003246845,0.0348325,0.0001330043,0.004076407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012653,"threshold_uncertainty_score":0.005837083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031618743055331,"score_gpt":0.3127252702862144,"score_spread":0.2924090828556611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}