{"id":"W2767525887","doi":"10.1093/neuonc/nox168.943","title":"STEM-28. DOT1L EPIGENETICALLY REGULATES GBM BRAIN TUMOR STEM CELLS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Hotchkiss Brain Institute; Ontario Brain Institute","funders":"","keywords":"Biology; Cancer research; Epigenetics; Stem cell; Carcinogenesis; DNA methylation; Gene silencing; Histone; Cancer stem cell; Cancer; Cell biology; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006360924,0.0001735256,0.0001944932,0.0001848175,0.000146643,0.0002438524,0.0001154306,0.000172763,0.002451294],"category_scores_gemma":[0.00006525677,0.00008870033,0.0001997907,0.0001373974,0.0001646369,0.0001000552,0.0001576948,0.0003347101,0.0006211125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732491,"about_ca_system_score_gemma":0.0002588276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127048,"about_ca_topic_score_gemma":0.002234266,"domain_scores_codex":[0.9999149,0.000007348826,0.000006798154,0.00002624282,0.00002934794,0.00001545],"domain_scores_gemma":[0.9999533,0.000004191167,0.00001855575,0.000003197546,0.000007686243,0.00001314105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001692011,0.00003547003,0.0007914732,0.00009093735,0.000007799465,0.00005656258,0.00002678711,0.0001612065,0.9921972,0.0002316263,0.0003486867,0.005883059],"study_design_scores_gemma":[0.00004116097,0.0003986079,0.03312359,0.00001894122,0.0000324131,0.000247788,0.00006128311,0.001652521,0.9497947,0.0001463701,0.01447524,0.000007456867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795547,0.005272634,0.003979855,0.0004204965,0.00007940417,0.00006656248,0.004800119,0.0004076113,0.00541859],"genre_scores_gemma":[0.9871151,0.001296536,0.001239244,0.0002296206,0.000006880623,0.0000479374,0.003569629,0.00003489021,0.006460287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002451294,"threshold_uncertainty_score":0.008200407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976916725985499,"score_gpt":0.2873144401354264,"score_spread":0.2675452728755714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}