{"id":"W2767557583","doi":"10.1186/s40360-017-0173-2","title":"Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)","year":2017,"lang":"en","type":"article","venue":"BMC Pharmacology and Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Interdisciplinary Research in Rehabilitation; Institut Universitaire en Santé Mentale de Québec","funders":"","keywords":"CYP2C19; Venlafaxine; CYP2D6; Medicine; Pharmacology; Dextromethorphan; Fexofenadine; Pharmacokinetics; CYP2C9; Internal medicine; Antidepressant; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003988052,0.001061448,0.001471861,0.0005065367,0.002799432,0.0001674921,0.00161768,0.0004600031,0.001079674],"category_scores_gemma":[0.0003716033,0.0009447708,0.0001842072,0.0004212057,0.001280348,0.0007160049,0.001200268,0.002304609,0.00007766537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001484845,"about_ca_system_score_gemma":0.000324147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001655494,"about_ca_topic_score_gemma":0.0001503451,"domain_scores_codex":[0.9908998,0.003762896,0.001133994,0.001987524,0.0004405651,0.00177521],"domain_scores_gemma":[0.9954719,0.00125706,0.0008693999,0.001087283,0.0003096211,0.001004732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005889498,0.02885787,0.8568345,0.0003506814,0.003463405,0.000971985,0.009250435,0.002659714,0.04743531,0.000352158,0.0007125931,0.04322181],"study_design_scores_gemma":[0.05854187,0.003112167,0.8622087,0.00002075672,0.006647833,0.0003181,0.002450053,0.03207454,0.01085466,0.0003066564,0.02125299,0.002211672],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843151,0.0007900234,0.0008173808,0.0004373795,0.004606898,0.005187914,0.00006747621,0.000268958,0.003508872],"genre_scores_gemma":[0.9929995,0.0004657885,0.00107238,0.001106737,0.001330984,0.002533128,0.0000172633,0.0001180351,0.0003562123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05265237,"threshold_uncertainty_score":0.9999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2965094400008791,"score_gpt":0.4360354109922349,"score_spread":0.1395259709913558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}