{"id":"W2767564843","doi":"10.1093/neuonc/nox168.099","title":"ATIM-02. DURABLE RESPONSES OBSERVED IN IDH1 WILDTYPE AND MUTANT RECURRENT HIGH GRADE GLIOMA (rHGG) WITH TOCA 511 & TOCA FC TREATMENT","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute","funders":"","keywords":"Bevacizumab; Medicine; Cancer; Cytosine deaminase; Cancer research; Immune system; Wild type; Glioma; Internal medicine; Mutant; Immunology; Biology; Chemotherapy; Genetic enhancement; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000339138,0.000473977,0.0009341915,0.0002888685,0.0001862885,0.000380286,0.0003913599,0.00055598,0.001871334],"category_scores_gemma":[0.0002226035,0.000157282,0.0004277964,0.0002520663,0.0002488865,0.0002152328,0.0001620792,0.001088244,0.0005719076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007129452,"about_ca_system_score_gemma":0.0005038415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002088297,"about_ca_topic_score_gemma":0.005392618,"domain_scores_codex":[0.9998512,0.00002798794,0.000007359629,0.00002332341,0.000023404,0.00006663239],"domain_scores_gemma":[0.9998852,0.00001496482,0.00001831994,0.0000192735,0.000007534335,0.00005473413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09518456,0.0240632,0.01151277,0.0007112646,0.0006653417,0.002651011,0.0003839353,0.004976388,0.5967473,0.0009221599,0.01209328,0.2500887],"study_design_scores_gemma":[0.04630945,0.5604521,0.1080388,0.0000765714,0.0007630216,0.00942086,0.0002739255,0.0080977,0.2335931,0.0005852577,0.03229425,0.00009508675],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945628,0.001009308,0.0003316163,0.0001538491,0.00004807983,0.0002167176,0.0006630794,0.0001821815,0.0028323],"genre_scores_gemma":[0.9950525,0.0003499973,0.0005638699,0.0002051335,0.00001923552,0.0001564837,0.001651014,0.00002657701,0.001975306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002088297,"threshold_uncertainty_score":0.006260276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998439439065296,"score_gpt":0.2995881393830823,"score_spread":0.2596037449924293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}