{"id":"W2767574526","doi":"10.1182/blood-2017-05-787598","title":"CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Research UK; Wellcome Trust","keywords":"T-cell receptor; Transgene; Biology; Cancer research; CRISPR; Immunology; Molecular biology; Cell biology; T cell; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794402,0.0002803473,0.0002478505,0.0002075559,0.00009696023,0.0004891444,0.0001967568,0.0003602033,0.0018649],"category_scores_gemma":[0.0002257895,0.00009799151,0.0001546232,0.0001281869,0.000179963,0.000122737,0.0001516927,0.0005508762,0.0003437695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000210397,"about_ca_system_score_gemma":0.0001809848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004483295,"about_ca_topic_score_gemma":0.0008307738,"domain_scores_codex":[0.9997489,0.00003986705,0.00002784565,0.00006426515,0.00006301975,0.00005603126],"domain_scores_gemma":[0.9998845,0.00003448486,0.00002757005,0.00001853902,0.000008693125,0.00002620137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001048207,0.00003672367,0.0002343043,0.00001868354,0.000009225495,0.00006809389,0.00001303365,0.0002060323,0.9958151,0.0001899119,0.0001198267,0.00318424],"study_design_scores_gemma":[0.0000536795,0.000396946,0.001632761,0.000004744273,0.00005396824,0.0006312135,0.00001632352,0.001919834,0.9899677,0.0001036939,0.005213316,0.000005887256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847996,0.0007289553,0.00940085,0.0001810598,0.00006153004,0.00005026574,0.0006087171,0.0005549152,0.003614023],"genre_scores_gemma":[0.9955272,0.0002289373,0.002434067,0.00003881586,0.000009655343,0.00001253179,0.0003312264,0.00004064966,0.001377002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018649,"threshold_uncertainty_score":0.006238759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03413140843863632,"score_gpt":0.3280309917116137,"score_spread":0.2938995832729774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}