{"id":"W2767574526","doi":"10.1182/blood-2017-05-787598","title":"CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Research UK; Wellcome Trust","keywords":"T-cell receptor; Transgene; Biology; Cancer research; CRISPR; Immunology; Molecular biology; Cell biology; T cell; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003226734,0.0001819206,0.0003388027,0.0000776208,0.0002525575,0.0001117592,0.0002768127,0.0001082621,0.009827715],"category_scores_gemma":[0.00008622041,0.0001542194,0.0001434825,0.00007310042,0.0001720435,0.00007762168,0.00005814785,0.0002450209,0.0003172763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003396643,"about_ca_system_score_gemma":0.000193035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001623533,"about_ca_topic_score_gemma":0.00006991782,"domain_scores_codex":[0.998353,0.00004505931,0.0002509137,0.0003971998,0.0004805426,0.0004733099],"domain_scores_gemma":[0.9983956,0.00005263432,0.00006119891,0.001118553,0.000122965,0.0002490138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003695012,0.0004898018,0.02847874,0.00007124432,0.0002551173,0.00008610694,0.0002478256,5.108639e-7,0.9672153,0.000009023142,0.001130881,0.001645942],"study_design_scores_gemma":[0.007912339,0.0005595975,0.01992567,0.00005262882,0.0002074104,0.00002754425,0.00004632263,0.00008739036,0.9398169,0.0000111402,0.0311671,0.0001859721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880668,0.0006269022,0.00002022729,0.00142646,0.0002497739,0.0006230674,0.00002895163,0.00006892493,0.008888913],"genre_scores_gemma":[0.9799969,0.001202554,0.0003702002,0.0003189794,0.0005007759,0.00006308226,0.00002589872,0.00005400707,0.01746766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03003622,"threshold_uncertainty_score":0.9910774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03413140843863632,"score_gpt":0.3280309917116137,"score_spread":0.2938995832729774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}