{"id":"W2767581845","doi":"10.1093/neuonc/nox168.033","title":"ACTR-42. INITIAL EXPERIENCE OF BLOOD-BRAIN BARRIER OPENING FOR CHEMOTHERAPEUTIC-DRUG DELIVERY TO BRAIN TUMOURS BY MR-GUIDED FOCUSED ULTRASOUND","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Microbubbles; Blood–brain barrier; Extravasation; Magnetic resonance imaging; Glioma; Focused ultrasound; Ultrasound; Drug delivery; Radiology; Nuclear medicine; Pathology; Central nervous system; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001767163,0.000820543,0.0008511822,0.000375797,0.0005540737,0.0006064675,0.0004733916,0.0007675542,0.002171351],"category_scores_gemma":[0.001187018,0.0002940345,0.0004125481,0.00029582,0.0005251337,0.0005695913,0.0005297394,0.001324918,0.001522224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003481561,"about_ca_system_score_gemma":0.0005695593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000541189,"about_ca_topic_score_gemma":0.0009143388,"domain_scores_codex":[0.9990579,0.000473226,0.00005199941,0.0001617371,0.0001348925,0.0001201186],"domain_scores_gemma":[0.9996365,0.0001226742,0.00003364334,0.0000582718,0.00003952046,0.0001093416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01490356,0.0134967,0.01062922,0.001042105,0.0002850599,0.00472647,0.002568591,0.002873362,0.5847709,0.001949505,0.007990849,0.3547638],"study_design_scores_gemma":[0.007907545,0.2637606,0.05359892,0.0002388665,0.0005580338,0.03577114,0.0004211084,0.006027691,0.4500484,0.001311456,0.1801313,0.0002248429],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944756,0.01362412,0.01351185,0.001846149,0.000206641,0.001105319,0.0005966433,0.0006780596,0.02367534],"genre_scores_gemma":[0.965304,0.00894863,0.01248772,0.00263968,0.0003177367,0.0009531051,0.001691797,0.0002459068,0.007411539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002171351,"threshold_uncertainty_score":0.00934571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715257738035372,"score_gpt":0.3096478137641074,"score_spread":0.2824952363837537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}