{"id":"W2767587783","doi":"10.1089/ars.2017.7082","title":"Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity","year":2017,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Cancer Society Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Thioredoxin reductase; Acetylation; Thioredoxin; Cell biology; Chemistry; Biochemistry; Reductase; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945557,0.0001423783,0.0001425889,0.0000326864,0.0006686086,0.0001031437,0.0001062429,0.0001754722,0.000006615451],"category_scores_gemma":[0.0001053081,0.0001208706,0.00003322819,0.00002232498,0.0003252763,0.0000280565,0.0001277622,0.00007721373,0.000001097608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002730743,"about_ca_system_score_gemma":0.00001734508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003064855,"about_ca_topic_score_gemma":0.000008726649,"domain_scores_codex":[0.9992195,0.00005965265,0.0001245801,0.0003607874,0.00006259616,0.0001729328],"domain_scores_gemma":[0.9994163,0.00001127357,0.0001759485,0.0002830231,0.00004960419,0.00006385831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008017012,0.00001691228,0.01379389,0.00001588248,0.00003869112,0.000002842239,0.00004591931,0.000007995213,0.9741731,0.0001892997,0.00002844515,0.01160685],"study_design_scores_gemma":[0.0004028394,0.00009871727,0.1724517,0.00004173352,0.00001870309,0.00002261028,0.00004937106,0.0001548897,0.8257937,0.0002886897,0.0005105825,0.0001664556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974415,0.0007643842,0.0008295148,0.0002577179,0.0001138768,0.0001196891,0.00001617157,0.0000110625,0.0004460895],"genre_scores_gemma":[0.9976044,0.00129213,0.000489789,0.00003757096,0.000190431,0.000004520228,0.00004277939,0.00001240419,0.0003260111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1586578,"threshold_uncertainty_score":0.5142465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131914388995771,"score_gpt":0.2724962310567807,"score_spread":0.261177087166823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}