{"id":"W2767589125","doi":"10.1038/s41598-017-14784-0","title":"Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Nova Scotia Health Research Foundation; Atlantic Canada Opportunities Agency; Blond McIndoe Research Foundation; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Apelin; Chemistry; Micelle; Membrane; Nuclear magnetic resonance spectroscopy; Gene isoform; Biophysics; Peptide; Stereochemistry; Biochemistry; Receptor; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908423,0.0002276599,0.000162096,0.0001094353,0.0001590673,0.0003480535,0.0001836194,0.0002052261,0.0008820229],"category_scores_gemma":[0.0003978232,0.0001270188,0.0001459977,0.0001199268,0.0002384135,0.0004027391,0.0002075102,0.0004586149,0.0002923557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002012535,"about_ca_system_score_gemma":0.0001533211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006132603,"about_ca_topic_score_gemma":0.0005023365,"domain_scores_codex":[0.999821,0.00002263752,0.00001095456,0.00005238199,0.00005098633,0.00004202165],"domain_scores_gemma":[0.999843,0.00004075609,0.00004125811,0.00001504949,0.00003822967,0.00002161005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004902282,0.000006325028,0.0001484968,0.00001006095,0.000002669819,0.0000138766,0.00002627185,0.00003548458,0.9992468,0.00002924968,0.000009395154,0.0004223159],"study_design_scores_gemma":[0.00000339969,0.00006123661,0.002305367,0.000002158635,0.000006710306,0.00005734762,0.00003262692,0.0008967799,0.9961386,0.00003381194,0.0004565802,0.000005323771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958947,0.0003583308,0.002756703,0.00003509149,0.000008806521,0.00001238425,0.0000981903,0.00004321282,0.000792678],"genre_scores_gemma":[0.9964618,0.0003958892,0.001766879,0.00005410996,0.000005503548,0.00002808704,0.0002258917,0.00001605846,0.001045798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008820229,"threshold_uncertainty_score":0.002950668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04031405305608312,"score_gpt":0.3501587789226931,"score_spread":0.30984472586661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}