{"id":"W2767591606","doi":"10.1139/cjc-2017-0393","title":"Catalytic asymmetric Friedel–Crafts synthesis of 1,1′-diaryl-2-substituted 4-pentenes enables stereoselective access to functionalized tetrahydronaphthalenes","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Chemistry; Stereoselectivity; Allylic rearrangement; Catalysis; Aryl; Friedel–Crafts reaction; Alkyl; Brønsted–Lowry acid–base theory; Lewis acids and bases; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004177717,0.0003719392,0.0008500678,0.00056494,0.0004860808,0.0003617634,0.002091173,0.0002577245,0.001250435],"category_scores_gemma":[0.005162305,0.0003546455,0.0004579461,0.0006120496,0.0002780516,0.0005883289,0.0001023667,0.0003124487,0.00001383304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004425208,"about_ca_system_score_gemma":0.001799948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00520339,"about_ca_topic_score_gemma":0.001524001,"domain_scores_codex":[0.9975606,0.00002190631,0.00087082,0.0003978309,0.0005820407,0.0005667934],"domain_scores_gemma":[0.995338,0.0004878612,0.001283772,0.0009360644,0.0008193928,0.001134928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008332596,0.0006187003,0.291722,0.002451977,0.006019748,0.001722989,0.0006556166,0.000395112,0.1372756,0.00007263253,0.01463487,0.5435975],"study_design_scores_gemma":[0.0005742172,0.00001521591,0.01257704,0.0004815136,0.0003879249,0.0002805504,0.0004196202,0.00002096722,0.9759765,0.0001131979,0.008700438,0.0004527787],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.857219,0.003117485,0.0001523546,0.0007765852,0.00034166,0.0001067059,0.0004069831,0.00001888793,0.1378604],"genre_scores_gemma":[0.9979385,0.00008176771,0.0001345892,0.00003662664,0.0003977691,0.00001909346,0.00001808641,0.00004833475,0.001325259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.838701,"threshold_uncertainty_score":0.9998906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289883946982993,"score_gpt":0.2515565386918799,"score_spread":0.22865769922205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}