{"id":"W2767608780","doi":"10.1007/s00262-017-2088-6","title":"Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Isfahan University of Medical Sciences; Iran National Science Foundation","keywords":"FOXP3; Immune system; Tumor microenvironment; Immunology; Regulatory T cell; Immunotherapy; Myeloid-derived Suppressor Cell; Cancer research; Melanoma; Population; Biology; T cell; Medicine; IL-2 receptor; Suppressor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0009684275,0.001008962,0.00160589,0.0005121182,0.001391754,0.0001879819,0.001857035,0.001068258,0.0006124847],"category_scores_gemma":[0.0001813773,0.0009762715,0.0002913307,0.0001873765,0.001715634,0.0007389662,0.0007339401,0.001471326,0.0001092975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898829,"about_ca_system_score_gemma":0.0005048446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001255683,"about_ca_topic_score_gemma":0.00008285731,"domain_scores_codex":[0.9947494,0.0006615019,0.00142345,0.001391082,0.0001276688,0.001646879],"domain_scores_gemma":[0.9953963,0.0004179857,0.001306562,0.002584515,0.0002425474,0.00005214886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004491224,0.0002557669,0.002609188,0.0001286766,0.0007778634,0.00003448691,0.001554621,0.0001016725,0.9785528,0.00005885514,0.0003251116,0.01110977],"study_design_scores_gemma":[0.009817199,0.0004609993,0.08139772,0.0001679004,0.00008704715,0.00005609791,0.0003002377,0.0001473372,0.9013104,0.0002105836,0.005047202,0.0009972781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8550968,0.1391078,0.00005193949,0.0008652894,0.003319983,0.001147788,0.0001061742,0.0001783071,0.0001259223],"genre_scores_gemma":[0.9768838,0.01725549,0.0005391423,0.0003941495,0.00009065202,0.000553568,0.00004887578,0.0002246893,0.004009658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1218523,"threshold_uncertainty_score":0.9999083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189419720479676,"score_gpt":0.2530133189182112,"score_spread":0.2411191217134145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}