{"id":"W2767613513","doi":"10.1093/neuonc/nox168.036","title":"ACTR-45. A PHASE 1, MULTICENTER, OPEN-LABEL STUDY OF MARIZOMIB (MRZ) WITH TEMOZOLOMIDE (TMZ) AND RADIOTHERAPY (RT) IN NEWLY DIAGNOSED WHO GRADE IV MALIGNANT GLIOMA (GLIOBLASTOMA, ndGBM)","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Concomitant; Medicine; Temozolomide; Nausea; Glioma; Internal medicine; Vomiting; Interim analysis; Tolerability; Surgery; Radiation therapy; Adverse effect; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001749376,0.002346728,0.001708856,0.000866788,0.0006706598,0.001249001,0.001432162,0.001631009,0.003990898],"category_scores_gemma":[0.0008630234,0.00101504,0.001609317,0.0006148109,0.001058766,0.001032341,0.0004454823,0.003218546,0.002018776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00122365,"about_ca_system_score_gemma":0.002325919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002219863,"about_ca_topic_score_gemma":0.006869195,"domain_scores_codex":[0.999122,0.0004225272,0.00003955813,0.0001619429,0.00009713158,0.0001568952],"domain_scores_gemma":[0.9993494,0.00005673468,0.0001398932,0.00006788738,0.00003977078,0.0003462608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6271006,0.1001145,0.006845636,0.001240477,0.002065264,0.0002963011,0.0005541106,0.005477415,0.1146141,0.001370957,0.01521765,0.1251029],"study_design_scores_gemma":[0.596952,0.3655841,0.01213585,0.00005173159,0.0009184207,0.0004665199,0.00007387635,0.002634983,0.01063628,0.0005702288,0.009910678,0.00006541132],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725792,0.004419178,0.002189394,0.0007958693,0.0003088711,0.008332916,0.004120563,0.0008496794,0.006404463],"genre_scores_gemma":[0.963342,0.002886693,0.00632496,0.001753514,0.0002475918,0.009752739,0.008429441,0.0001715453,0.00709148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003990898,"threshold_uncertainty_score":0.01335084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03918978322584706,"score_gpt":0.3592807108428105,"score_spread":0.3200909276169634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}