{"id":"W2767623417","doi":"10.1093/neuonc/nox168.212","title":"CSIG-18. RALOXIFENE SENSITIZES GLIOBLASTOMA CELLS TO HYPOXIA-INDUCED DEATH THROUGH INHIBITION OF RNA STRESS GRANULE DISSOLUTION","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Dalhousie University","funders":"","keywords":"Raloxifene; Stress granule; Hypoxia (environmental); Autophagy; Programmed cell death; Apoptosis; Cancer research; Chemistry; Selective estrogen receptor modulator; Downregulation and upregulation; Pharmacology; Medicine; Cell biology; Biology; Estrogen receptor; Internal medicine; Messenger RNA; Translation (biology); Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008970567,0.0003864616,0.0006714935,0.0005472875,0.0001743251,0.0002955466,0.0002409579,0.0002478985,0.00175968],"category_scores_gemma":[0.00008303756,0.0001677025,0.0004504675,0.0004858558,0.000143814,0.0001095222,0.0001655991,0.0004064026,0.0004776963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003234278,"about_ca_system_score_gemma":0.0003891785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00238274,"about_ca_topic_score_gemma":0.008210295,"domain_scores_codex":[0.9999044,0.000009658588,0.000009424272,0.00001847863,0.00002549968,0.00003247913],"domain_scores_gemma":[0.9999623,0.000005296755,0.000008970071,0.000004210612,0.000007651582,0.00001155085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006750471,0.00024091,0.0008884322,0.0002125761,0.00004521939,0.0001222283,0.00003053051,0.0002581256,0.9771517,0.00009434088,0.0007298478,0.01955108],"study_design_scores_gemma":[0.0003799637,0.004285442,0.0156372,0.00001971876,0.0001340326,0.0006454365,0.00004131548,0.001089212,0.9631016,0.00006876952,0.01457759,0.00001992264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806421,0.008260086,0.001849143,0.0002775441,0.00005942439,0.0002445579,0.003226992,0.0005357303,0.004904505],"genre_scores_gemma":[0.9764686,0.006417314,0.003807247,0.0002555417,0.00001778105,0.0001901098,0.006398882,0.00004169226,0.006402868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00238274,"threshold_uncertainty_score":0.005886734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063657841755859,"score_gpt":0.3197846394331111,"score_spread":0.2891480610155525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}