{"id":"W2767697997","doi":"10.1093/neuonc/nox168.217","title":"CSIG-23. CIC PROTEIN INSTABILITY DRIVES CANCER PHENOTYPES IN GLIOBLASTOMA","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"MAPK/ERK pathway; Cancer research; Signal transduction; Biology; Receptor tyrosine kinase; Ubiquitin ligase; Kinase; Cell biology; Carcinogenesis; Cancer; Ubiquitin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001880859,0.0002044823,0.00026575,0.00007248687,0.000234683,0.00004807126,0.0005375473,0.0003045089,0.0001410056],"category_scores_gemma":[0.0009486781,0.0002055844,0.00009221354,0.00005873925,0.0003162301,0.0000187446,0.0003669705,0.0003505543,0.00005887424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226093,"about_ca_system_score_gemma":0.0003669223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003860135,"about_ca_topic_score_gemma":0.007846683,"domain_scores_codex":[0.9983861,0.0002347345,0.0002998001,0.0005937038,0.0001102205,0.0003754643],"domain_scores_gemma":[0.9986053,0.00004457601,0.0002446011,0.0008950276,0.0001110109,0.00009955303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003551497,0.0001967119,0.01067346,0.00001771071,0.0000221089,0.00002993539,0.0001016312,0.00002556411,0.9740962,0.00009006296,0.0007318018,0.01365962],"study_design_scores_gemma":[0.0009056267,0.001007696,0.0143806,0.00002143863,0.00001176322,0.00002411019,0.00005188182,0.00003583228,0.7293888,0.0002581067,0.2536967,0.0002175031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910443,0.0002155981,0.00007215328,0.002391558,0.0006994588,0.0006824809,0.00002501225,0.00002530258,0.004844174],"genre_scores_gemma":[0.9978448,0.00008158792,0.0003313311,0.0004568257,0.0003818433,0.0005506002,0.000008137962,0.00003231276,0.00031257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2529649,"threshold_uncertainty_score":0.838349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01622152431319565,"score_gpt":0.3197615835393039,"score_spread":0.3035400592261082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}