{"id":"W2767697997","doi":"10.1093/neuonc/nox168.217","title":"CSIG-23. CIC PROTEIN INSTABILITY DRIVES CANCER PHENOTYPES IN GLIOBLASTOMA","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"MAPK/ERK pathway; Cancer research; Signal transduction; Biology; Receptor tyrosine kinase; Ubiquitin ligase; Kinase; Cell biology; Carcinogenesis; Cancer; Ubiquitin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141087,0.0003410022,0.0003380535,0.0003911472,0.0002395596,0.0003318641,0.0002988153,0.0003413242,0.002442453],"category_scores_gemma":[0.0001154423,0.0001586052,0.0002399265,0.0003480708,0.000329762,0.00007377374,0.0002410139,0.0005331417,0.001155222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006793843,"about_ca_system_score_gemma":0.0004199324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003024523,"about_ca_topic_score_gemma":0.00475745,"domain_scores_codex":[0.9998049,0.00002586172,0.00002546123,0.00003684479,0.00005640891,0.00005050669],"domain_scores_gemma":[0.9997937,0.00002419235,0.00005705008,0.00002605263,0.0000119434,0.00008703397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008360462,0.00003693672,0.000222537,0.00001915954,0.000006691021,0.0001799451,0.00001267253,0.00006572122,0.9982566,0.0001300453,0.0001619428,0.0008241211],"study_design_scores_gemma":[0.00002577846,0.0003637739,0.01547749,0.00001045623,0.00002156292,0.001356781,0.00007493713,0.001795611,0.973233,0.0001122561,0.007516843,0.00001149978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918957,0.0007893174,0.001127147,0.0002361815,0.00006709056,0.0000569489,0.002343931,0.00029629,0.003187514],"genre_scores_gemma":[0.9914188,0.0003397223,0.001104879,0.0001121043,0.000009924852,0.00004624396,0.002267653,0.00008559883,0.004614891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003024523,"threshold_uncertainty_score":0.008170784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01622152431319565,"score_gpt":0.3197615835393039,"score_spread":0.3035400592261082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}