{"id":"W2767705098","doi":"10.3390/molecules22111948","title":"Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Residue (chemistry); Chemistry; Substrate (aquarium); Alkylation; Biochemistry; Stereochemistry; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538475,0.0004286252,0.0002944225,0.0002092517,0.00007727267,0.0002791638,0.0002353489,0.0003147991,0.001158448],"category_scores_gemma":[0.0002278529,0.0001769617,0.0002735096,0.0001750352,0.0002010575,0.0001745676,0.0003088662,0.0004413962,0.0003573079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942443,"about_ca_system_score_gemma":0.0001870547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004566053,"about_ca_topic_score_gemma":0.000448577,"domain_scores_codex":[0.9997666,0.00004907476,0.00003134869,0.00004920805,0.0000673268,0.00003641311],"domain_scores_gemma":[0.9997956,0.00004178919,0.00007379957,0.00002797314,0.00001919206,0.00004166647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007011868,0.00002332198,0.0001375238,0.00001346424,0.000004153607,0.00003861608,0.000005835596,0.00004266273,0.9991093,0.00003638979,0.000007053043,0.0005114012],"study_design_scores_gemma":[0.000005999585,0.0004025644,0.001501003,0.000002895115,0.00001563409,0.0004280081,0.0000132569,0.000456,0.9963034,0.00002097823,0.0008455306,0.000004517931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997418,0.0002003087,0.001769613,0.00004155712,0.0000127211,0.000009703378,0.0001174616,0.00005703068,0.0003736164],"genre_scores_gemma":[0.9963084,0.0001427979,0.00229757,0.00003259056,0.000006201562,0.000008784523,0.0003791528,0.00003749749,0.0007870732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158448,"threshold_uncertainty_score":0.003875375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694087780037861,"score_gpt":0.2592361051580711,"score_spread":0.2422952273576924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}