{"id":"W2767708353","doi":"10.1002/jcph.1029","title":"Pharmacokinetics, Immunogenicity, and Efficacy of Etanercept in Pediatric Patients With Moderate to Severe Plaque Psoriasis","year":2017,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"U.S. Food and Drug Administration; Wyeth; Pfizer","keywords":"Etanercept; Medicine; Psoriasis; Psoriasis Area and Severity Index; Dosing; Pharmacokinetics; Pharmacodynamics; Immunogenicity; Internal medicine; Arthritis; Body mass index; Gastroenterology; Immunology; Antibody; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005730246,0.0001935541,0.0004680581,0.0001494055,0.0001352686,0.0003043111,0.00008188863,0.0001679234,0.0004658649],"category_scores_gemma":[0.001582172,0.0001582695,0.0002336236,0.0002000964,0.0001725512,0.0002970899,0.00008853799,0.0004874715,0.0001282209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003144751,"about_ca_system_score_gemma":0.0003057678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000594506,"about_ca_topic_score_gemma":0.0006096765,"domain_scores_codex":[0.9997036,0.0001301732,0.00002331327,0.0000369333,0.00007120593,0.00003479357],"domain_scores_gemma":[0.9992464,0.0003010782,0.0002665348,0.00003822129,0.00006143843,0.00008635467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01516291,0.001260877,0.8515583,0.0001936182,0.0002946858,0.001954991,0.0005550919,0.001842467,0.05503933,0.0001903817,0.0008556802,0.07109178],"study_design_scores_gemma":[0.0007840282,0.01958541,0.9571176,0.00003025695,0.0002768196,0.007209995,0.0002759903,0.002081855,0.01018484,0.0001094619,0.002328089,0.00001578103],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988407,0.0006597103,0.0001822567,0.00002104548,0.000001939796,0.00001120055,0.00005814412,0.000005660096,0.0002193535],"genre_scores_gemma":[0.9990237,0.0004296255,0.0002618326,0.00004042275,0.000008377422,0.00001249049,0.0001382,0.000003721921,0.00008173746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000594506,"threshold_uncertainty_score":0.003030479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04913036369912428,"score_gpt":0.4181918679754371,"score_spread":0.3690615042763128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}