{"id":"W2767763411","doi":"10.1093/hmg/ddx393","title":"Loss of CHCHD10–CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS","year":2017,"lang":"de","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto; Sunnybrook Health Science Centre; Occupational Cancer Research Centre; Health Sciences Centre; McGill University","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst; Muscular Dystrophy Association","keywords":"Biology; Immunoprecipitation; Mitochondrion; Mutation; Galactose; Cell biology; Cell culture; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128326,0.0006437257,0.0002983288,0.0003692818,0.0002353437,0.0003095401,0.0002539975,0.0004227006,0.00130443],"category_scores_gemma":[0.0001836026,0.0002544626,0.0002821239,0.0001938149,0.0004099751,0.0001739325,0.000340448,0.0005105362,0.000515513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000439648,"about_ca_system_score_gemma":0.0001908481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001275741,"about_ca_topic_score_gemma":0.001566891,"domain_scores_codex":[0.9997835,0.00002711367,0.00003194655,0.00006470877,0.00006117932,0.00003166583],"domain_scores_gemma":[0.9998129,0.0000295647,0.00004425866,0.00001869784,0.00001504388,0.0000795888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005550612,0.0000141771,0.0005614241,0.00001095701,0.000004795811,0.0003618808,0.00001356977,0.00002043409,0.9986911,0.00002079543,0.00001719189,0.0002281707],"study_design_scores_gemma":[0.00003446607,0.0002185964,0.05072836,0.000007451166,0.00003178789,0.007369804,0.0001093324,0.001361926,0.9383265,0.0001157417,0.00168465,0.0000114214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982247,0.0003575928,0.0008090239,0.00004947671,0.00001814914,0.00001032191,0.0002173924,0.00003766008,0.0002756375],"genre_scores_gemma":[0.9979249,0.0001677744,0.0007789565,0.00003007455,0.000007039551,0.00001172091,0.0003890636,0.00001759749,0.0006728198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130443,"threshold_uncertainty_score":0.004363716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09999233847062533,"score_gpt":0.3796450235211906,"score_spread":0.2796526850505652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}