{"id":"W2767767832","doi":"10.1074/jbc.m117.806562","title":"Structure–function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Heme; Chemistry; Hemoglobin; Ligand (biochemistry); Staphylococcus aureus; Biochemistry; Stereochemistry; Receptor; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333696,0.0003420664,0.0002935623,0.0001454244,0.0001495924,0.000209212,0.0002456914,0.0003279483,0.001055799],"category_scores_gemma":[0.0001937724,0.00008678395,0.0003572035,0.0002375927,0.0001446301,0.0001467321,0.0001500088,0.0004423804,0.0002097845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004006359,"about_ca_system_score_gemma":0.0002116951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003540565,"about_ca_topic_score_gemma":0.00233229,"domain_scores_codex":[0.9999114,0.00001435776,0.000005946713,0.00001521959,0.00003413378,0.00001890893],"domain_scores_gemma":[0.9999173,0.00001684502,0.00002212006,0.000004328939,0.00001681378,0.00002256854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008374449,0.0002076185,0.00932876,0.0001627037,0.0000900521,0.001409088,0.0002357158,0.00338725,0.9773983,0.0005920276,0.0006839072,0.005667163],"study_design_scores_gemma":[0.0001682755,0.0009478715,0.1732285,0.00005838101,0.000191683,0.004440324,0.0004001751,0.08295377,0.7291062,0.0007054309,0.007712306,0.00008714048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975131,0.0006326055,0.001077473,0.00007758021,0.000009718232,0.000007650337,0.0002288789,0.00003628809,0.0004166477],"genre_scores_gemma":[0.9975556,0.0002254213,0.00104628,0.00004362488,0.000003185702,0.000005504862,0.0006867134,0.00001126601,0.0004224319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003540565,"threshold_uncertainty_score":0.007039905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784263545215626,"score_gpt":0.3062467125483695,"score_spread":0.2784040770962133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}