{"id":"W2767773345","doi":"10.1016/j.aca.2017.10.016","title":"Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS)","year":2017,"lang":"en","type":"article","venue":"Analytica Chimica Acta","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Chemistry; Chromatography; Analyte; Mass spectrometry; Tandem mass spectrometry; Whole blood; Everolimus; Sample preparation; Quantitative analysis (chemistry); Detection limit; Sirolimus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074707,0.001104752,0.0007356097,0.001399196,0.0005457946,0.0007007538,0.0007851581,0.001324732,0.001309401],"category_scores_gemma":[0.001915023,0.0005398711,0.0004104283,0.0005933979,0.0006266587,0.0006777188,0.0004990261,0.001186184,0.001216245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004340308,"about_ca_system_score_gemma":0.001226169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646293,"about_ca_topic_score_gemma":0.002874672,"domain_scores_codex":[0.9987311,0.0001686649,0.00006425087,0.0003458571,0.0006101031,0.00008009109],"domain_scores_gemma":[0.9991803,0.0001960457,0.0001239951,0.00007008815,0.0003420533,0.00008748253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004692797,0.00007242747,0.003515273,0.0001530852,0.00006640002,0.0001404855,0.00006223034,0.00009484687,0.9722863,0.0002596346,0.001004738,0.02187531],"study_design_scores_gemma":[0.00007679432,0.000721016,0.01553456,0.00005516149,0.0001010233,0.002566696,0.00007402203,0.006759355,0.9674609,0.0005017866,0.00609049,0.000058156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6172529,0.02893115,0.3263737,0.00153564,0.001359202,0.001350332,0.006208002,0.005961209,0.01102783],"genre_scores_gemma":[0.7441053,0.006783599,0.2349139,0.003294357,0.0003118725,0.0007426458,0.002414155,0.0002769835,0.007157164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646293,"threshold_uncertainty_score":0.005683661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133453650685422,"score_gpt":0.2852170408186716,"score_spread":0.2718716757501294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}