{"id":"W2767804576","doi":"10.1038/s41467-017-01231-x","title":"Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cytokinesis; Cleavage furrow; Formins; Cell biology; Actin; Protein filament; RHOA; Actin remodeling; MDia1; Septin; Actin remodeling of neurons; Biology; Treadmilling; Cytoskeleton; Chemistry; Actin cytoskeleton; Cell division; Microfilament; Cell; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920237,0.0001529586,0.0001231214,0.00003882456,0.001055288,0.0001669931,0.001195876,0.0002892269,0.000078402],"category_scores_gemma":[0.0002428991,0.000152072,0.00009418285,0.00005056174,0.0001108695,0.0000366178,0.0004058526,0.0004348337,0.00002553794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004583337,"about_ca_system_score_gemma":0.00003836651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005359869,"about_ca_topic_score_gemma":0.0003181406,"domain_scores_codex":[0.999079,0.00007445779,0.0002070281,0.000337219,0.0001242979,0.0001780126],"domain_scores_gemma":[0.9957221,0.00001302732,0.0002337546,0.003774738,0.0001717977,0.00008455625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005447633,0.0002562988,0.0001213043,0.000003380289,0.00003926962,2.579243e-7,0.00004169761,0.00000148916,0.9220038,0.001092412,0.07172362,0.004661994],"study_design_scores_gemma":[0.0001712314,0.00007936337,0.0005181303,0.00001016412,0.00001490062,0.000008535576,0.0001096916,0.0001220817,0.2820923,0.00006282438,0.7166689,0.0001418104],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335137,0.01072778,0.002735909,0.02819636,0.003149878,0.001343452,0.0003374679,0.0001699097,0.01982554],"genre_scores_gemma":[0.9909934,0.003052534,0.002506773,0.0002238774,0.0002576408,0.00005680199,0.0008939653,0.00003381118,0.001981187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6449453,"threshold_uncertainty_score":0.811653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02516515728424051,"score_gpt":0.3185072966374642,"score_spread":0.2933421393532237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}