{"id":"W2767841440","doi":"10.1021/acs.jproteome.7b00270","title":"Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis","year":2017,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; University of Manitoba; Spinal Cord Injury Canada","keywords":"Experimental autoimmune encephalomyelitis; Citrullination; Myelin basic protein; Acetylation; Lysine; Multiple sclerosis; Myelin oligodendrocyte glycoprotein; Arginine; Encephalomyelitis; Myelin; Chemistry; Immunology; Citrulline; Biochemistry; Medicine; Biology; Neuroscience; Central nervous system; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529753,0.000598211,0.0004434875,0.0007295492,0.0002281033,0.0002756531,0.0001735916,0.0003933969,0.001216774],"category_scores_gemma":[0.0001098149,0.0002010084,0.0003220905,0.000407087,0.0002938857,0.0002439626,0.0002048035,0.0009886364,0.0003224596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850102,"about_ca_system_score_gemma":0.0001695714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006104358,"about_ca_topic_score_gemma":0.001265545,"domain_scores_codex":[0.9997779,0.00002282506,0.00002029119,0.00005132485,0.00006630182,0.00006146694],"domain_scores_gemma":[0.9997308,0.00001416391,0.0001072722,0.00001375512,0.00002862386,0.0001053876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002610739,0.00004333409,0.0005754765,0.00002911239,0.00001037854,0.00003672893,0.0000113691,0.00001039194,0.9984494,0.000009761795,0.00001873294,0.0005441713],"study_design_scores_gemma":[0.00002737879,0.001255586,0.05909852,0.00001194766,0.00005751873,0.0005227657,0.00005284814,0.0003340915,0.9375625,0.0000640909,0.001002846,0.000009815636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940434,0.002235216,0.001841717,0.0001024129,0.00003590527,0.00002922356,0.0006498756,0.0000962311,0.0009659622],"genre_scores_gemma":[0.9910734,0.001789341,0.002844812,0.0001094828,0.00002097069,0.00008245125,0.001143904,0.00003126507,0.002904431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216774,"threshold_uncertainty_score":0.00407052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.071306543506195,"score_gpt":0.3343446416447336,"score_spread":0.2630380981385386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}