{"id":"W2767867701","doi":"10.3389/fmicb.2017.02176","title":"Site-Directed Mutagenesis Study Revealed Three Important Residues in Hc-DAF-22, a Key Enzyme Regulating Diapause of Haemonchus contortus","year":2017,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Natural Science Foundation of Zhejiang Province; Fundamental Research Funds for the Central Universities; Chinese Academy of Sciences; Institute of Genetics; National Natural Science Foundation of China; National Key Research and Development Program of China; University of Minnesota","keywords":"Haemonchus contortus; Biology; Mutant; RNA interference; Caenorhabditis elegans; Mutagenesis; Molecular biology; Gene; Biochemistry; Cell biology; Genetics; Nematode; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310879,0.0005454058,0.0002795844,0.000164559,0.0002187648,0.0001320459,0.0002566015,0.0003334313,0.001088506],"category_scores_gemma":[0.0001474734,0.0001178538,0.0004472611,0.0001441449,0.0002286843,0.0001229935,0.0001687214,0.0005412785,0.0004008111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002243603,"about_ca_system_score_gemma":0.0003245748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001461454,"about_ca_topic_score_gemma":0.002039871,"domain_scores_codex":[0.9999069,0.00001261916,0.0000116861,0.00002308513,0.0000309126,0.00001485492],"domain_scores_gemma":[0.9998455,0.00002924449,0.00004759505,0.00001161018,0.00002403472,0.00004193716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919781,0.00005488093,0.0006692331,0.00009617547,0.00002588412,0.0008675726,0.00004415454,0.0002446933,0.9952602,0.000310217,0.000103388,0.00213169],"study_design_scores_gemma":[0.00007606983,0.0004243385,0.01904139,0.00003592212,0.0001693345,0.002377337,0.0001086364,0.004186749,0.9658251,0.0001474935,0.00756892,0.00003866533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857814,0.001102706,0.00984181,0.0001690648,0.000162481,0.00009060549,0.0007659852,0.0001067198,0.001979261],"genre_scores_gemma":[0.9923242,0.0005242969,0.00427486,0.00009704097,0.00001595461,0.00002883963,0.0007545773,0.00003300608,0.001947191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461454,"threshold_uncertainty_score":0.003641367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071704823348954,"score_gpt":0.2402240777866539,"score_spread":0.2295070295531644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}