{"id":"W2767882965","doi":"10.1016/j.sbi.2017.09.005","title":"Laboratory evolution of protein conformational dynamics","year":2017,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Conformational ensembles; Molecular dynamics; Dynamics (music); Evolutionary dynamics; Protein evolution; Protein dynamics; Computational biology; Conformational change; Computer science; Chemistry; Biophysics; Biology; Physics; Computational chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001781131,0.0003890938,0.0009141561,0.0001942672,0.00007914036,0.00001592704,0.000586771,0.0007235357,0.00001142416],"category_scores_gemma":[0.0001734717,0.0003171792,0.0002567577,0.0001139358,0.0003164701,0.0000100211,0.0002621086,0.0003772753,0.000004829203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524207,"about_ca_system_score_gemma":0.0006559545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001616584,"about_ca_topic_score_gemma":0.00001275869,"domain_scores_codex":[0.9981942,0.0001882693,0.0007833529,0.0004384403,0.0001059368,0.0002898057],"domain_scores_gemma":[0.9982259,0.00001545024,0.0009585939,0.0005893685,0.0001528232,0.00005783202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003128396,0.00001223711,0.0002999564,0.009508894,0.00007570443,1.642984e-7,0.00000732214,0.00000319993,0.00008746269,0.02896515,0.00008615474,0.9609225],"study_design_scores_gemma":[0.0003418043,0.0001316913,0.0001592579,0.002672777,0.0000306455,0.0000179741,0.000005352265,0.0001012758,0.00001528447,0.001793995,0.9943093,0.0004206212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003784827,0.9934415,0.0004113393,0.000006096007,0.003293261,0.0008378756,0.00152513,0.000008945932,0.00009738723],"genre_scores_gemma":[0.002841326,0.9878457,0.0002367425,0.000001696019,0.0006457969,0.0001133173,0.008271397,0.0000251407,0.00001888363],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9942232,"threshold_uncertainty_score":0.9999281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04405233692788697,"score_gpt":0.3858145690532198,"score_spread":0.3417622321253329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}