{"id":"W2767889889","doi":"10.1016/j.jocn.2017.10.060","title":"Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)","year":2017,"lang":"en","type":"review","venue":"Journal of Clinical Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"","keywords":"Leukoencephalopathy; Leukodystrophy; CADASIL; Medicine; Pathology; Microglia; White matter; Neuroscience; Disease; Immunology; Biology; Inflammation; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000712019,0.001164129,0.002385804,0.004156702,0.0002722701,0.001423877,0.001102732,0.001608797,0.002350328],"category_scores_gemma":[0.0009531417,0.0003685976,0.0006414191,0.003678664,0.0006197421,0.001900825,0.001216982,0.001635773,0.001217799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005447657,"about_ca_system_score_gemma":0.001533587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125373,"about_ca_topic_score_gemma":0.002821468,"domain_scores_codex":[0.9997267,0.00003760695,0.00007705722,0.00004926374,0.00008350742,0.00002580599],"domain_scores_gemma":[0.9994528,0.000252176,0.0001146344,0.00001393394,0.00010771,0.00005877193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001611907,0.0000773928,0.0003838729,0.03319076,0.0002084103,0.0009209412,0.000090988,0.0003326061,0.001652221,0.00264393,0.02987827,0.9304594],"study_design_scores_gemma":[0.00006039082,0.0001280374,0.001741967,0.01162479,0.0005741263,0.007848765,0.0001733216,0.0001512554,0.0005663962,0.00231842,0.9747585,0.00005397582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006099058,0.9994889,0.00005837087,0.0001008065,0.0001079475,0.000001903479,0.000009960797,0.000003301354,0.0001676624],"genre_scores_gemma":[0.000419055,0.9989457,0.0001408133,0.0001295664,0.0001761223,0.000002679514,0.00002281267,8.818395e-7,0.0001624143],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004156702,"threshold_uncertainty_score":0.007862628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1087281069346446,"score_gpt":0.3828114558003873,"score_spread":0.2740833488657426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}