{"id":"W2767890943","doi":"10.7554/elife.29830","title":"The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity","year":2017,"lang":"en","type":"article","venue":"eLife","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Leukemia and Lymphoma Society","keywords":"EIF4E; Hyaluronidase; Hyaluronic acid; Biosynthesis; Translation (biology); Cell biology; Biochemistry; Extracellular; Glucosamine; Protein biosynthesis; Chemistry; Biology; Enzyme; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550102,0.0002883842,0.0001724472,0.0001834778,0.0001724309,0.000349967,0.0001165079,0.000194956,0.0004968006],"category_scores_gemma":[0.0001205786,0.0001180038,0.0001605265,0.0001542136,0.0002555641,0.0001890769,0.0003281491,0.0003742124,0.0002669404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003443171,"about_ca_system_score_gemma":0.0002110872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002860708,"about_ca_topic_score_gemma":0.0004856898,"domain_scores_codex":[0.9999095,0.00001156573,0.000007682178,0.00001822061,0.00002806347,0.00002500195],"domain_scores_gemma":[0.9999437,0.000009935494,0.00001806251,0.000007910638,0.000008443612,0.00001184476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006428298,0.00001202744,0.0004945969,0.00003589524,0.000004681276,0.00004434678,0.0000101159,0.0001876888,0.9946683,0.0004168754,0.00009695163,0.003964331],"study_design_scores_gemma":[0.000009495282,0.0000811725,0.002923247,0.000005861757,0.000007133728,0.0001329744,0.0000251869,0.00127244,0.9869152,0.0002400614,0.008383311,0.000003852786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788008,0.004136022,0.0107955,0.000486723,0.0001187873,0.00003207208,0.0004883881,0.0001846452,0.004956961],"genre_scores_gemma":[0.9898344,0.001745419,0.005133026,0.00008116353,0.0000190092,0.0000145471,0.0004038891,0.00002488812,0.002743723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004968006,"threshold_uncertainty_score":0.002498209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936839366885068,"score_gpt":0.3271952257868777,"score_spread":0.2778268321180269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}