{"id":"W2767946275","doi":"10.1093/neuonc/nox168.398","title":"GENE-24. ATRX DEFICIENCY IN GLIOMA CELLS OF ORIGIN PROMOTES DISEASE-DEFINING PHENOTYPES BY WAY OF GLOBAL EPIGENOMIC REMODELING","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Biology; Epigenomics; Epigenetics; Genetics; Carcinogenesis; Histone; Cancer research; DNA methylation; Mutation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268996,0.0001769274,0.00033392,0.00003072534,0.00009845161,0.00001369688,0.0004561573,0.00018542,0.000008932876],"category_scores_gemma":[0.0001746471,0.0001775043,0.0001116261,0.00006234779,0.0001851646,0.000006765816,0.0001907316,0.0001044253,0.000004984301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007487746,"about_ca_system_score_gemma":0.0003975182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002111998,"about_ca_topic_score_gemma":0.0001110872,"domain_scores_codex":[0.9985656,0.00009421971,0.0004499198,0.0004484718,0.0001321691,0.0003096707],"domain_scores_gemma":[0.9987996,0.00003258237,0.0003980661,0.0005918058,0.00008683928,0.00009112163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001925221,0.0001356362,0.01054547,0.00005476301,0.00001157569,0.00001141842,0.00004992855,0.001849646,0.9777207,0.00004714647,0.0003043969,0.009076813],"study_design_scores_gemma":[0.001524992,0.0007740046,0.002034033,0.00005004379,0.00005780455,0.00002392243,0.00004969321,0.005112066,0.9851073,0.0005171969,0.004438445,0.0003104951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951671,0.002604848,0.0004503269,0.0001158084,0.0003797719,0.0001734009,0.0001143475,0.00001022837,0.0009841552],"genre_scores_gemma":[0.9979456,0.0002253863,0.001606032,0.00006568224,0.00008170931,0.0000103702,0.0000275766,0.00002276021,0.000014866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008766319,"threshold_uncertainty_score":0.7238415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678159308447616,"score_gpt":0.290826121728091,"score_spread":0.2740445286436149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}