{"id":"W2767946275","doi":"10.1093/neuonc/nox168.398","title":"GENE-24. ATRX DEFICIENCY IN GLIOMA CELLS OF ORIGIN PROMOTES DISEASE-DEFINING PHENOTYPES BY WAY OF GLOBAL EPIGENOMIC REMODELING","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Biology; Epigenomics; Epigenetics; Genetics; Carcinogenesis; Histone; Cancer research; DNA methylation; Mutation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038563,0.0003191695,0.0001973846,0.0002489501,0.0001295847,0.0002861611,0.0002082906,0.0002231501,0.002311635],"category_scores_gemma":[0.00004965929,0.000124343,0.0003269868,0.0001390898,0.000235113,0.0001304205,0.0001948269,0.0004919556,0.0008068033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398926,"about_ca_system_score_gemma":0.0002232424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007510497,"about_ca_topic_score_gemma":0.001206172,"domain_scores_codex":[0.9998564,0.00002410232,0.0000212046,0.00003770279,0.00003512571,0.00002545919],"domain_scores_gemma":[0.9999031,0.00001431423,0.00002884211,0.00001683401,0.000006353942,0.0000305436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006095105,0.00002070508,0.0001256317,0.00001978687,0.000004266294,0.00008124299,0.00001212359,0.00005187041,0.9987231,0.0001275525,0.00003189952,0.0007408439],"study_design_scores_gemma":[0.00000912453,0.0002372143,0.002990723,0.000005436978,0.00001556143,0.000335466,0.00002350192,0.0005772887,0.9921353,0.00003780927,0.003630182,0.000002444252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888362,0.001714926,0.004160169,0.0001182329,0.0000490283,0.00005022124,0.00208212,0.0002532605,0.002735829],"genre_scores_gemma":[0.986276,0.0008608015,0.00318132,0.00004388928,0.000005712448,0.00006263103,0.002367554,0.00004423785,0.007157738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311635,"threshold_uncertainty_score":0.007733226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678159308447616,"score_gpt":0.290826121728091,"score_spread":0.2740445286436149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}