{"id":"W2767954326","doi":"10.3390/antibiotics6040026","title":"Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities","year":2017,"lang":"en","type":"review","venue":"Antibiotics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Topoisomerase; DNA gyrase; Etoposide; Topoisomerase IV; Topoisomerase inhibitor; Teniposide; Chemistry; DNA; Biology; Pharmacology; Biochemistry; Gene; Genetics; Chemotherapy; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003500181,0.0006038627,0.0007666492,0.001730507,0.0002812304,0.0008201025,0.0005817098,0.0007227823,0.00226775],"category_scores_gemma":[0.0003783247,0.0002264719,0.0002943113,0.001508982,0.0005044821,0.001287932,0.0005592273,0.00138099,0.001427007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007083751,"about_ca_system_score_gemma":0.0007490091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007124959,"about_ca_topic_score_gemma":0.001410591,"domain_scores_codex":[0.9998453,0.00002258632,0.00002102764,0.00003195008,0.00006007781,0.00001906757],"domain_scores_gemma":[0.9998415,0.00006060326,0.00002568961,0.000006422078,0.00004752297,0.0000182375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005774237,0.00004941436,0.0002214319,0.01134091,0.00004554978,0.0002370756,0.00008848483,0.0003418515,0.006775599,0.009933553,0.01681133,0.9540969],"study_design_scores_gemma":[0.000005659713,0.00005990886,0.0004586036,0.0008869693,0.00002899239,0.0009612088,0.00003970129,0.00006383722,0.001385419,0.001609853,0.9944876,0.00001234436],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002919919,0.9970593,0.0002634897,0.0003038315,0.0001544878,0.000003695297,0.00002008687,0.00001274786,0.001890435],"genre_scores_gemma":[0.001832266,0.9966887,0.0002854938,0.0001695102,0.0001253977,0.000005608648,0.0000290031,0.000002127589,0.0008618811],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00226775,"threshold_uncertainty_score":0.00758636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05511242376832954,"score_gpt":0.3691225613983724,"score_spread":0.3140101376300428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}