{"id":"W2767954326","doi":"10.3390/antibiotics6040026","title":"Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities","year":2017,"lang":"en","type":"review","venue":"Antibiotics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Topoisomerase; DNA gyrase; Etoposide; Topoisomerase IV; Topoisomerase inhibitor; Teniposide; Chemistry; DNA; Biology; Pharmacology; Biochemistry; Gene; Genetics; Chemotherapy; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001728314,0.0002796855,0.0007501289,0.00004552276,0.0001553817,0.00007000083,0.0003434996,0.0007194498,0.00000364629],"category_scores_gemma":[0.00002950535,0.0001935695,0.0002120836,0.00004231623,0.0002471868,0.000004399052,0.0002111416,0.0002601422,9.919548e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001141063,"about_ca_system_score_gemma":0.0001917626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207613,"about_ca_topic_score_gemma":0.00001478694,"domain_scores_codex":[0.9989693,0.00006678341,0.0002930577,0.0003300951,0.0001352149,0.0002055085],"domain_scores_gemma":[0.9987357,0.00003421144,0.0004827439,0.0006588383,0.00005177273,0.00003676143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001701382,0.00001629362,0.00007850386,0.002683316,0.0004500349,0.000001440606,0.00002966872,1.023434e-7,0.006535748,0.0003211402,0.000122863,0.9897439],"study_design_scores_gemma":[0.0001411484,0.0001723032,0.0001012358,0.001186162,0.0006178365,0.0000145251,0.00001359241,5.702361e-7,0.01285403,0.00003895618,0.9846134,0.0002462553],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008638781,0.9896129,0.00006198342,0.00002623297,0.0007719698,0.0003773429,0.0003519211,0.000006464923,0.000152376],"genre_scores_gemma":[0.07070331,0.9277079,0.00006968014,0.00002865287,0.001101802,6.718071e-7,0.0001687916,0.00004243105,0.0001767363],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9894976,"threshold_uncertainty_score":0.7893535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05511242376832954,"score_gpt":0.3691225613983724,"score_spread":0.3140101376300428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}