{"id":"W2767955451","doi":"10.1002/cbic.201700521","title":"Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Universiteit Utrecht","keywords":"Processivity; Mechanism (biology); Chemistry; Biophysics; Computational chemistry; Computational biology; Biology; Physics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135443,0.000145925,0.0002567398,0.0000630111,0.0001169652,0.00004125617,0.0001957432,0.0002363815,0.00002292242],"category_scores_gemma":[0.0002098621,0.0001497185,0.0001197901,0.0001005334,0.000121895,0.000006379431,0.0001586478,0.00005791986,9.283625e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001761639,"about_ca_system_score_gemma":0.00006167099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007388386,"about_ca_topic_score_gemma":0.00008093723,"domain_scores_codex":[0.9990807,0.00001991971,0.0002137501,0.0003823211,0.0001395302,0.0001638359],"domain_scores_gemma":[0.9988457,0.000005950374,0.0003269222,0.0006014747,0.000149488,0.00007048625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008691426,0.00003326871,0.001401563,0.00004249155,0.0004493569,4.55072e-7,0.0000488081,0.00002586321,0.996496,0.00005499579,0.00008816143,0.001272119],"study_design_scores_gemma":[0.0007386426,0.00006531718,0.0153154,0.00001495543,0.000460911,0.00000212217,0.00001015908,0.000614287,0.9821624,0.000159101,0.0002945021,0.0001621793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980623,0.0002570487,0.000938176,0.00005912562,0.0001982479,0.0001775967,0.00003263381,0.000009002513,0.0002659415],"genre_scores_gemma":[0.9986645,0.00006566726,0.0003891503,0.00001038499,0.0002911531,0.00001554346,0.0001507417,0.00001599354,0.0003968392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01433358,"threshold_uncertainty_score":0.6105345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380643714508937,"score_gpt":0.2811335450928371,"score_spread":0.2673271079477477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}