{"id":"W2767969226","doi":"10.1093/neuonc/nox168.791","title":"PDTM-27. DIANHYDROGALACTITOL (VAL-083) OVERCOMES CHEMORESISTANCE IN PEDIATRIC MALIGNANT BRAIN TUMORS AND DISPLAYS SYNERGY WITH TOPOISOMERASE INHIBITORS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada); University of British Columbia","funders":"","keywords":"Temozolomide; Cancer research; Medulloblastoma; DNA repair; Glioma; Methyltransferase; Cancer; Topoisomerase; Medicine; Cell cycle; Cell cycle checkpoint; Biology; Internal medicine; DNA; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005182999,0.0003533714,0.0002965039,0.0002194201,0.00008760444,0.0001626489,0.0002365182,0.0001751118,0.001285954],"category_scores_gemma":[0.00005693022,0.0001115805,0.000205866,0.0002089207,0.0001064797,0.00009494187,0.000168651,0.0006129117,0.0003694734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511255,"about_ca_system_score_gemma":0.0002747272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410491,"about_ca_topic_score_gemma":0.002192448,"domain_scores_codex":[0.9999623,0.000006259653,0.000002264594,0.000006263952,0.000007175585,0.00001576619],"domain_scores_gemma":[0.9999714,0.000002935977,0.000005753997,0.00000252194,0.000002363148,0.00001502374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002268004,0.0007883801,0.0009157012,0.0002395109,0.00005673636,0.000342331,0.0000643873,0.00131247,0.9240841,0.0004475666,0.002019682,0.06746124],"study_design_scores_gemma":[0.001243426,0.01367097,0.01765951,0.0000295047,0.0001153741,0.002456756,0.00006137332,0.002792352,0.9285968,0.0001651356,0.03318239,0.00002642281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893326,0.004548658,0.0008197287,0.0001905934,0.00003730546,0.00006962063,0.0005471196,0.0003785146,0.004075924],"genre_scores_gemma":[0.9940261,0.002156378,0.001033576,0.00008833321,0.0000109629,0.00004964177,0.00104205,0.00003642241,0.001556616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410491,"threshold_uncertainty_score":0.004301906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018727026139224,"score_gpt":0.2693073971770693,"score_spread":0.259120126915677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}