{"id":"W2767988375","doi":"10.1093/neuonc/nox168.955","title":"STEM-41. A SUBSET OF GBM BRAIN TUMOR STEM CELL LINES ARE UNIQUELY DEPENDENT ON GLUTAMINE METABOLISM FOR AMINO ACID SYNTHESIS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Ontario Brain Institute; University of Calgary","funders":"","keywords":"Glutamine; Glutaminase; Stem cell; Biology; Cancer research; Glutamate receptor; Metabolism; Cancer stem cell; Cell culture; Glutamine synthetase; Amino acid; Biochemistry; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002469944,0.0005971162,0.0005925057,0.0005162054,0.000399809,0.0005068409,0.000275424,0.0004879504,0.004165952],"category_scores_gemma":[0.0001819662,0.000184609,0.0004567975,0.0005122083,0.0002646198,0.0002451328,0.0002378869,0.0008408873,0.001835588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002513871,"about_ca_system_score_gemma":0.0004872179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102903,"about_ca_topic_score_gemma":0.002188907,"domain_scores_codex":[0.9996499,0.00003134852,0.00004530144,0.00005106188,0.0001765523,0.00004575652],"domain_scores_gemma":[0.9998634,0.0000234906,0.00002468529,0.00002389003,0.00002827407,0.00003626822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002928306,0.0003129533,0.002657591,0.0002356971,0.00003340649,0.0004197407,0.0001581711,0.0002747669,0.9727349,0.001325955,0.002420188,0.01913392],"study_design_scores_gemma":[0.0001114417,0.001789553,0.01863632,0.00005066643,0.00009806042,0.00173539,0.0001481579,0.001680564,0.8925542,0.000720786,0.08244511,0.00002982255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9264495,0.01173537,0.0143526,0.001521875,0.0004112086,0.001020555,0.01819787,0.001554626,0.02475646],"genre_scores_gemma":[0.91353,0.00703042,0.0120029,0.001390893,0.00008309079,0.001288094,0.04056953,0.0001179598,0.02398717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004165952,"threshold_uncertainty_score":0.01393646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02255241527387001,"score_gpt":0.2772148034173769,"score_spread":0.2546623881435068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}