{"id":"W2768017127","doi":"10.1101/202440","title":"Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitosis; Cell biology; Polo-like kinase; Nuclear localization sequence; PLK1; Ran; Biology; NLS; Mitotic exit; Centrosome; Cyclin-dependent kinase 1; Cytokinesis; Kinase; Prophase; Phosphorylation; Phosphatase; Spindle apparatus; Cytoplasm; Cell cycle; Biochemistry; Cell division; Meiosis; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124967,0.0002101436,0.000163161,0.0001154297,0.0001860087,0.0004125548,0.0001994328,0.0002334557,0.001475616],"category_scores_gemma":[0.0001600625,0.0001442659,0.0001168389,0.00007042001,0.0002792272,0.0002339618,0.0003264205,0.0004357446,0.0006228633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005311767,"about_ca_system_score_gemma":0.0002252356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005427881,"about_ca_topic_score_gemma":0.001048054,"domain_scores_codex":[0.999887,0.00001361105,0.0000138543,0.00003620045,0.00002451501,0.00002483495],"domain_scores_gemma":[0.9998525,0.00002436909,0.00005150722,0.00002381607,0.00001004993,0.00003769431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009459112,0.00001065931,0.0002511391,0.00001509151,0.000001149038,0.00009089091,0.000007172117,0.00003820143,0.9988167,0.000179824,0.00003731081,0.0004572272],"study_design_scores_gemma":[0.00001504617,0.00002908405,0.005582147,0.000006622764,0.000002635683,0.0002196216,0.00002287054,0.001086452,0.9909797,0.0001026053,0.001949673,0.000003574468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940615,0.0007178535,0.002847295,0.0001527045,0.00003847888,0.00001680766,0.0002858222,0.0001249521,0.00175438],"genre_scores_gemma":[0.9964526,0.0001702806,0.001176489,0.00004030938,0.000006145253,0.00001033389,0.0003371513,0.00003111355,0.00177554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475616,"threshold_uncertainty_score":0.004936397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008354259537846048,"score_gpt":0.215655473021344,"score_spread":0.2073012134834979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}